UniProt Accession

 GPX1_MOUSE; P11352; P12079; Q544W3; Q5RJH8; Q9CR54 

Genbank Protein ID

 X03920; AK002245; AK010999; AK011019; AK028171; AK150548; AK154833; AK160388; BC086649; X15667 

Genbank Nucleotide ID

 CAA27558.1; BAC55244.1; BAC55252.1; BAC55253.1; BAC55257.1; BAE29650.1; BAE32862.1; BAE35760.1; AAH86649.1; CAB43535.1 

Protein Name

 Glutathione peroxidase 1 

Protein Synonyms/Alias

 GPx-1; GSHPx-1; Cellular glutathione peroxidase; Selenium-dependent glutathione peroxidase 1 

Gene Name

 Gpx1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	TEMNDLQKRLGPRGL	acetylation	[1, 2, 3, 4, 5, 6, 7]
62	TEMNDLQKRLGPRGL	succinylation	[6]
62	TEMNDLQKRLGPRGL	ubiquitination	[8]
86	FGHQENGKNEEILNS	acetylation	[2, 3, 4, 5, 6, 7]
86	FGHQENGKNEEILNS	succinylation	[6]
86	FGHQENGKNEEILNS	ubiquitination	[8]
95	EEILNSLKYVRPGGG	acetylation	[2, 3, 6, 7]
95	EEILNSLKYVRPGGG	succinylation	[6]
112	PNFTLFEKCEVNGEK	acetylation	[1, 2, 3, 4, 5, 6, 7]
112	PNFTLFEKCEVNGEK	succinylation	[6]
119	KCEVNGEKAHPLFTF	acetylation	[3, 5, 7]
119	KCEVNGEKAHPLFTF	ubiquitination	[8]
146	TALMTDPKYIIWSPV	acetylation	[2, 5, 6, 7, 9]
146	TALMTDPKYIIWSPV	succinylation	[6]
146	TALMTDPKYIIWSPV	ubiquitination	[8]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [7] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [8] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [9] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 

Functional Description

 Protects the hemoglobin in erythrocytes from oxidative breakdown. 

Sequence Annotation

 ACT_SITE 47 47
 MOD_RES 146 146 N6-acetyllysine.
 MOD_RES 201 201 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Oxidoreductase; Peroxidase; Phosphoprotein; Reference proteome; Selenocysteine. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004866; F:endopeptidase inhibitor activity; IEA:Compara.
 GO:0004602; F:glutathione peroxidase activity; IDA:MGI.
 GO:0060055; P:angiogenesis involved in wound healing; IMP:MGI.
 GO:0043534; P:blood vessel endothelial cell migration; IMP:MGI.
 GO:0045454; P:cell redox homeostasis; IEA:Compara.
 GO:0001885; P:endothelial cell development; IMP:MGI.
 GO:0045444; P:fat cell differentiation; IMP:MGI.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0060047; P:heart contraction; IMP:MGI.
 GO:0042744; P:hydrogen peroxide catabolic process; IMP:MGI.
 GO:0006917; P:induction of apoptosis; IMP:MGI.
 GO:0051702; P:interaction with symbiont; IGI:MGI.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IMP:MGI.
 GO:0051450; P:myoblast proliferation; IMP:MGI.
 GO:0014902; P:myotube differentiation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IGI:MGI.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:MGI.
 GO:0018158; P:protein oxidation; IMP:MGI.
 GO:0040029; P:regulation of gene expression, epigenetic; IEA:Compara.
 GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0043523; P:regulation of neuron apoptotic process; IMP:MGI.
 GO:0061136; P:regulation of proteasomal protein catabolic process; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IGI:MGI.
 GO:0033194; P:response to hydroperoxide; IMP:MGI.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0009609; P:response to symbiotic bacterium; IGI:MGI.
 GO:0009636; P:response to toxic substance; IMP:MGI.
 GO:0009410; P:response to xenobiotic stimulus; IMP:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0048741; P:skeletal muscle fiber development; IMP:MGI.
 GO:0043403; P:skeletal muscle tissue regeneration; IMP:MGI.
 GO:0001659; P:temperature homeostasis; IGI:MGI.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI.
 GO:0009650; P:UV protection; IEA:Compara.
 GO:0042311; P:vasodilation; IMP:MGI. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.