CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial 
Protein Synonyms/Alias
 Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma 
Gene Name
 IDH3G 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
149YANVIHCKSLPGVVTubiquitination[1]
221KKVTAVHKANIMKLGubiquitination[1]
226VHKANIMKLGDGLFLubiquitination[1]
320TGKSIANKNIANPTAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 NP_BIND 56 84 NAD (Potential).
 NP_BIND 309 316 ATP (Potential).
 METAL 254 254 Magnesium or manganese (By similarity).
 BINDING 136 136 Substrate (By similarity).
 BINDING 167 167 Substrate (By similarity).
 BINDING 254 254 Substrate (By similarity).
 MOD_RES 363 363 Phosphothreonine (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Nucleotide-binding; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK YGGRHTVTMI 60
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 120
NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 180
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 240
ARYPQITFEN MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 300
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 360
MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA 393 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc.
 GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.
 GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR004434; Isocitrate_DH_NAD.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS