| Tag | Content |
|---|
| CPLM ID | CPLM-016090 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | USP6 N-terminal-like protein |
Protein Synonyms/Alias | |
Gene Name | Usp6nl |
Gene Synonyms/Alias | Kiaa0019 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 244 | HHEKILNKFLSKLKQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (By similarity). |
Sequence Annotation | DOMAIN 100 292 Rab-GAP TBC.
MOD_RES 389 389 Phosphoserine (By similarity).
MOD_RES 394 394 Phosphoserine (By similarity).
MOD_RES 544 544 Phosphoserine.
MOD_RES 574 574 Phosphoserine (By similarity).
MOD_RES 631 631 Phosphoserine (By similarity).
MOD_RES 644 644 Phosphoserine (By similarity).
MOD_RES 648 648 Phosphoserine (By similarity).
MOD_RES 662 662 Phosphoserine.
MOD_RES 669 669 Phosphoserine (By similarity).
MOD_RES 704 704 Phosphoserine (By similarity).
MOD_RES 717 717 Phosphotyrosine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; GTPase activation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 819 AA |
Protein Sequence | MNSDQDVALK LAQERAEIVA KYDRGREGAE IEPWEDADYL VYKVTDRFGF LHEEELPYHN 60
AAADRQKQLE IERTSKWLKM LKKWERYKNT EKFHRRIYKG IPLQLRGEVW ALLLEIPKMK 120
EETRDLYSKL KHRARGCSPD IRQIDLDVNR TFRDHIMFRD RYGVKQQSLF HVLAAYSIYN 180
TEVGYCQGMS QITALLLMYM NEEDAFWALV KLFSGPKHAM HGFFVQGFPK LLRFQEHHEK 240
ILNKFLSKLK QHLDSQEIYT SFYTMKWFFQ CFLDRTPFRL NLRIWDIYIF EGERVLTAMS 300
YTILKLHKKH LMKLSMEELV EFLQETLAKD FFFEDDFVIE QLQVSMAELK RAKLDLPEPG 360
KEDEYPKKPL GQLPPESACV NHLSNGQRSV GRPSPKTSSR REDGSPRKNH EHSPVHHSRN 420
GTPERAGQSR RKSVDEGSKN LKHEAESQRK PSPGMQDSSR HYNHAAANQN SNAISNVRKE 480
FMPKWRKPSD ASAIERTTKY AVEGKSHSAL PALPVAIPGS AETRLPNSRQ KMKALDGGEG 540
KRGSNASQYD NVPGGESEHG ASAEEGPERT HPHSPRKHPE PSPSPPKVPN KFTFKVQPPS 600
HVRYPPQLPE EDHRAAYPPS YSNPPVYHGN SPKHVPTAHS GFVSTQISPR PQINPSRRPY 660
GSSLSVDTSP EKAYSRPTPV VLPSSRIEVL PIDMGARGYG SSGSPKNGQF ILPPVDYLPE 720
NRKWSEVSYT YRPEMHGQSW TRDAHRSHLS NLPNYAAFQH IPFQAHGLPE VSVDSPVRYK 780
MSAAVEDASP PGYPYAGPSP SAHHYRNGEG LSVQESVLL 819 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; ISS:UniProtKB. GO:0007030; P:Golgi organization; ISS:UniProtKB. GO:0035526; P:retrograde transport, plasma membrane to Golgi; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |