CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029834
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 CDK5 regulatory subunit-associated protein 2 
Protein Synonyms/Alias
  
Gene Name
 CDK5RAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18NKIFALRKQLEQDVLubiquitination[1, 2, 3]
32LSYQNLRKTLEEQISubiquitination[2]
81FSQEELKKKVSDLIQubiquitination[2]
82SQEELKKKVSDLIQLubiquitination[2]
91SDLIQLVKELYTDNQubiquitination[2]
101YTDNQHLKKTIFDLSubiquitination[2]
102TDNQHLKKTIFDLSCubiquitination[2]
131TEQTEIMKDLSKGGCubiquitination[2]
139DLSKGGCKNGYLRHTubiquitination[2]
149YLRHTESKISDCDGAubiquitination[2]
191ESRPDLLKVVRELLLubiquitination[2, 3]
222GKTEKTPKQKGELVHubiquitination[2]
224TEKTPKQKGELVHFVubiquitination[2]
253SCEAQLVKAGEVPKVubiquitination[2, 3]
263EVPKVGLKDASVQTVubiquitination[2, 3]
337SRLPILIKPSRSLGNubiquitination[2, 3]
398EGRPTPDKTLLNAQPubiquitination[2]
422PGEQKGIKTTSSVWRubiquitination[2]
479VATYLSSKSQPSAKVubiquitination[2]
485SKSQPSAKVSVMGTDubiquitination[2]
507SNETEYLKQKIHDLEubiquitination[2, 4, 5]
509ETEYLKQKIHDLETEubiquitination[2]
553GAQDGLSKPKNGSDGubiquitination[2, 3]
555QDGLSKPKNGSDGEEubiquitination[2]
578VRYVKHVKILGPLAPubiquitination[1, 2]
597SRVLENLKQQLEEQEubiquitination[2, 3, 4, 6]
606QLEEQEYKLQKEQNLubiquitination[2, 3]
609EQEYKLQKEQNLNMQubiquitination[1, 2, 3]
627EIHNLQNKFRDLSPPubiquitination[2, 5]
655SLQRQQIKDGHGICVubiquitination[2, 3]
714EKLFLNGKSVGVEMNubiquitination[2]
851SEIHFLRKQNQALNAubiquitination[2]
881LRESLSRKTVSLEHLubiquitination[2]
935SRVQEEVKLRQQLLSubiquitination[2]
956QSLRVELKAYEKLDEubiquitination[2]
960VELKAYEKLDEEHRRubiquitination[2]
1014STLQSRLKEQLARGAubiquitination[2]
1116GHHLWASKNGRHVLGubiquitination[2]
1163TSQELGTKGPHPAPLubiquitination[2]
1192EEAYRRLKLLWRVSLubiquitination[2]
1259DQLVVTHKILRKARGubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1287 AA 
Protein Sequence
DSINNLQAEL NKIFALRKQL EQDVLSYQNL RKTLEEQISE IRRREEESFS LYSDQTSYLS 60
ICLEENNRFQ VEHFSQEELK KKVSDLIQLV KELYTDNQHL KKTIFDLSCM GFQGNGFPDR 120
LASTEQTEIM KDLSKGGCKN GYLRHTESKI SDCDGAHAPG CLEEGAFINL LAPLFNEKAT 180
LLLESRPDLL KVVRELLLGQ LFLTEQEVSG EHLDGKTEKT PKQKGELVHF VQTNSFSKPH 240
DELKLSCEAQ LVKAGEVPKV GLKDASVQTV ATEGDLLRFK HEATREAWEE KPINTALSAE 300
HRPENLHGVP GWQAALLSLP GITNREAKKS RLPILIKPSR SLGNMYRLPA TQEVVTQLQS 360
QILELQGELK EFKTCNKQLH QKLILAEAVM EGRPTPDKTL LNAQPPVGAA YQDSPGEQKG 420
IKTTSSVWRD KEMDSDQQRS YEIDSEICPP DDLASLPSCK ENPEDVLSPT SVATYLSSKS 480
QPSAKVSVMG TDQSESINTS NETEYLKQKI HDLETELEGY QNFIFQLQKH SQCSEAIITV 540
LCGTEGAQDG LSKPKNGSDG EEMTFSSLHQ VRYVKHVKIL GPLAPEMIDS RVLENLKQQL 600
EEQEYKLQKE QNLNMQLFSE IHNLQNKFRD LSPPRYDSLV QSQARELSLQ RQQIKDGHGI 660
CVISRQHMNT MIKAFEELLQ ASDVDYCVAE GFQEQLNQCA ELLEKLEKLF LNGKSVGVEM 720
NTQNELMERI EEDNLTYQHL LPESPEPSAS HALSDYETSE KSFFSRDQKQ DNETEKTSVM 780
VNSFSQDLLM EHIQEIRTLR KRLEESIKTN EKLRKQLERQ GSEFVQGSTS IFASGSELHS 840
SLTSEIHFLR KQNQALNAML IKGSRDKQKE NDKLRESLSR KTVSLEHLQR EYASVKEENE 900
RLQKEGSEKE RHNQQLIQEV RCSGQELSRV QEEVKLRQQL LSQNDKLLQS LRVELKAYEK 960
LDEEHRRLRE ASGEGWKGQD PFRDLHSLLM EIQALRLQLE RSIETSSTLQ SRLKEQLARG 1020
AEKAQEGALT LAVQAVSIPE VPLQPDKHDG DKYPMESDNS FDLFDSSQAV TPKSVSETPP 1080
LSGNDTDSLS CDSGSSATST PCVSRLVTGH HLWASKNGRH VLGLIEDYEA LLKQISQGQR 1140
LLAEMDIQTQ EAPSSTSQEL GTKGPHPAPL SKFVSSVSTA KLTLEEAYRR LKLLWRVSLP 1200
EDGQCPLHCE QIGEMKAEVT KLHKKLFEQE KKLQNTMKLL QLSKRQEKVI FDQLVVTHKI 1260
LRKARGNLEL RPGGAHPGTC SPSRPGS 1287 
Gene Ontology
 GO:0030054; C:cell junction; IDA:HPA.
 GO:0005813; C:centrosome; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS