CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010123
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Ribosomal RNA small subunit methyltransferase H 
Protein Synonyms/Alias
 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH 
Gene Name
 rsmH 
Gene Synonyms/Alias
 mraW; MPN_315; MP521 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
119PERGFSFKHAGPFDMacetylation[1]
154EELTHVLKKFGEIAHacetylation[1]
197AAASNFEKYKSRNYLacetylation[1]
307AKLFVIEKK******acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity). 
Sequence Annotation
 REGION 35 37 S-adenosyl-L-methionine binding (By
 BINDING 54 54 S-adenosyl-L-methionine (By similarity).
 BINDING 80 80 S-adenosyl-L-methionine; via amide
 BINDING 101 101 S-adenosyl-L-methionine (By similarity).
 BINDING 108 108 S-adenosyl-L-methionine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; rRNA processing; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 308 AA 
Protein Sequence
MLSNQPHKSV LLDEVIHNLN IKGDGNYLDL TVGFGGHSQH ILEQLTTGTL TGNDMDKDSI 60
TFCTELFKDK KNVVLVHDNF ANFFNHLKQL KVTKFDGILI DLGVSSYQLD KPERGFSFKH 120
AGPFDMRMHQ SDRVPTALDI LERLSEEELT HVLKKFGEIA HPKPIAKALK TLINNTKNPT 180
TVEVAETVKA AASNFEKYKS RNYLAKVFQA IRIYLNRELE SLEIVLQHIP KLLNNKGRFL 240
VIVFHSLEEK LVRNYIFKLT HFVQPPELPV KLTPPFELIT KKPILPTEQE IKTNPRVRSA 300
KLFVIEKK 308 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0071424; F:rRNA (cytosine-N4-)-methyltransferase activity; IEA:HAMAP.
 GO:0070475; P:rRNA base methylation; IEA:HAMAP. 
Interpro
 IPR002903; RsmH.
 IPR023397; SAM-dep_MeTrfase_MraW_recog. 
Pfam
 PF01795; Methyltransf_5 
SMART
  
PROSITE
  
PRINTS