UniProt Accession

 DDX3L_MOUSE; P16381 

Genbank Protein ID

 J04847; AK029542 

Genbank Nucleotide ID

 AAA39942.1; BAC26505.1 

Protein Name

 Putative ATP-dependent RNA helicase Pl10 

Protein Synonyms/Alias

  

Gene Name

 D1Pas1 

Gene Synonyms/Alias

 Pl10 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
64	GSRWSKDKDAYSSFG	acetylation	[1]
214	KHAIPIIKEKRDLMA	ubiquitination	[2]
263	NGKYGRRKQYPISLV	ubiquitination	[2]
334	VDMMERGKIGLDFCK	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process. 

Sequence Annotation

 DOMAIN 210 402 Helicase ATP-binding.
 DOMAIN 413 574 Helicase C-terminal.
 NP_BIND 199 206 ATP (By similarity).
 NP_BIND 223 230 ATP (By similarity).
 MOTIF 179 207 Q motif.
 MOTIF 346 349 DEAD box.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 67 67 Phosphotyrosine (By similarity).
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 74 74 Phosphoserine (By similarity).
 MOD_RES 103 103 Phosphotyrosine (By similarity).
 MOD_RES 117 117 N6-acetyllysine (By similarity).
 MOD_RES 124 124 Phosphoserine (By similarity).
 MOD_RES 282 282 Phosphotyrosine.
 MOD_RES 342 342 Phosphotyrosine (By similarity).
 MOD_RES 465 465 Phosphotyrosine.
 MOD_RES 592 592 Phosphoserine (By similarity).
 MOD_RES 610 610 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Developmental protein; Differentiation; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Spermatogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 660 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS