CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium-dependent neutral amino acid transporter SLC6A17 
Protein Synonyms/Alias
 Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17 
Gene Name
 SLC6A17 
Gene Synonyms/Alias
 NTT4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34LEEPVDYKQSVLNVAubiquitination[1, 2, 3]
47VAGEAGGKQKAVEEEubiquitination[1, 3]
662YKKGRMMKDISNLEEubiquitination[1, 3]
679ETRFILSKVPSEAPSubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). 
Sequence Annotation
 MOD_RES 377 377 Phosphotyrosine (By similarity).
 MOD_RES 665 665 Phosphoserine (By similarity).
 MOD_RES 700 700 Phosphothreonine (By similarity).
 MOD_RES 722 722 Phosphothreonine (By similarity).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 393 393 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Neurotransmitter transport; Phosphoprotein; Polymorphism; Reference proteome; Symport; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 727 AA 
Protein Sequence
MPKNSKVTQR EHSSEHVTES VADLLALEEP VDYKQSVLNV AGEAGGKQKA VEEELDAEDR 60
PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV PYLVLLIIIG IPLFFLELAV 120
GQRIRRGSIG VWHYICPRLG GIGFSSCIVC LFVGLYYNVI IGWSIFYFFK SFQYPLPWSE 180
CPVVRNGSVA VVEAECEKSS ATTYFWYREA LDISDSISES GGLNWKMTLC LLVAWSIVGM 240
AVVKGIQSSG KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE 300
AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV VFAVLGFKAN 360
IMNEKCVVEN AEKILGYLNT NVLSRDLIPP HVNFSHLTTK DYMEMYNVIM TVKEDQFSAL 420
GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT HFPASPFWSV MFFLMLINLG LGSMIGTMAG 480
ITTPIIDTFK VPKEMFTVGC CVFAFLVGLL FVQRSGNYFV TMFDDYSATL PLTLIVILEN 540
IAVAWIYGTK KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVTPPGYSA 600
WIKEEAAERY LYFPNWAMAL LITLIVVATL PIPVVFVLRH FHLLSDGSNT LSVSYKKGRM 660
MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST SPLETSGNPN GRYGSGYLLA 720
STPESEL 727 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0032328; P:alanine transport; ISS:UniProtKB.
 GO:0015816; P:glycine transport; ISS:UniProtKB.
 GO:0015820; P:leucine transport; ISS:UniProtKB.
 GO:0015824; P:proline transport; ISS:UniProtKB. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002438; Na/ntran_symport_orphan. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR00176; NANEUSMPORT.
 PR01206; ORPHTRNSPORT.