CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017088
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribonucleoprotein PTB-binding 1 
Protein Synonyms/Alias
 Protein raver-1 
Gene Name
 RAVER1 
Gene Synonyms/Alias
 KIAA1978 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196AKSDLLGKPLGPRTLubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). 
Sequence Annotation
 DOMAIN 59 130 RRM 1.
 DOMAIN 132 210 RRM 2.
 DOMAIN 221 299 RRM 3.
 REGION 307 395 Interaction with PTBP1 (By similarity).
 MOTIF 45 60 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 463 463 Phosphothreonine.
 MOD_RES 474 474 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 606 AA 
Protein Sequence
MAADVSVTHR PPLSPKSGAE VEAGDAAERR APEEELPPLD PEEIRKRLEH TERQFRNRRK 60
ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL LNGEQAEAAI NAFHQSRLRE 120
RELSVQLQPT DALLCVANLP PSLTQQQFEE LVRPFGSLER CFLVYSERTG QSKGYGFAEY 180
MKKDSAARAK SDLLGKPLGP RTLYVHWTDA GQLTPALLHS RCLCVDRLPP GFNDVDALCR 240
ALSAVHSPTF CQLACGQDGQ LKGFAVLEYE TAEMAEEAQQ QADGLSLGGS HLRVSFCAPG 300
PPGRSMLAAL IAAQATALNR GKGLLPEPNI LQLLNNLGPS ASLQLLLNPL LHGSAGGKQG 360
LLGAPPAMPL LNGPALSTAL LQLALQTQGQ KKPGILGDSP LGALQPGAQP ANPLLGELPA 420
GGGLPPELPP RRGKPPPLLP SVLGPAGGDR EALGLGPPAA QLTPPPAPVG LRGSGLRGPL 480
SHFYSGSPTS YFTSGLQAGL KQSHLSKAIG SSPLGSGEGL LGLSPGPNGH SHLLKVRAGG 540
GDMQGWEAPA PQRPLTRPAL PSVSRPHWAA RNAALPTCCP RPSPAQKAAM WASTPRASAA 600
TTRTPT 606 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS