CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020652
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial-processing peptidase subunit beta 
Protein Synonyms/Alias
 Beta-MPP; P-52 
Gene Name
 Pmpcb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
235DYITTHYKGPRIVLAacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Cleaves presequences (transit peptides) from mitochondrial protein precursors (By similarity). 
Sequence Annotation
 ACT_SITE 104 104 Proton acceptor (By similarity).
 METAL 101 101 Zinc (By similarity).
 METAL 105 105 Zinc (By similarity).
 METAL 181 181 Zinc (By similarity).  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Protease; Reference proteome; Transit peptide; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 489 AA 
Protein Sequence
MAAAALSRTL LPEARRRLWG FTRRLPLRRA AAQPLYFGGD RLRSTQAAPQ VVLNVPETQV 60
TCLENGLRVA SENSGLSTCT VGLWIDAGSR YENEKNNGTA HFLEHMAFKG TKKRSQLDLE 120
LEIENMGAHL NAYTSREQTV YYAKAFSRDL PRAVEILADI IQNSTLGEAE IERERGVILR 180
EMQEVETNLQ EVVFDYLHAT AYQNTALGRT ILGPTENIKS INRKDLVDYI TTHYKGPRIV 240
LAAAGGVCHN ELLELAKFHF GDSLCSHKGA IPALPPCKFT GSEIRVRDDK MPLAHLAIAV 300
EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF QSFNTSYTDT 360
GLWGLYMVCE QATVADMLHV VQNEWKRLCT DVTESEVARA KNLLKTNMLL QLDGSTPICE 420
DIGRQMLCYN RRIPIPELEA RIDAVDAETV RRVCTKYIHD KSPAIAALGP IERLPDFNQI 480
CSNMRWIRD 489 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR001431; Pept_M16_Zn_BS.
 IPR007863; Peptidase_M16_C. 
Pfam
 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 
SMART
  
PROSITE
 PS00143; INSULINASE 
PRINTS