UniProt Accession

 SIR2_MOUSE; Q8VDQ8; Q9CXS5; Q9EQ18; Q9ERJ9 

Genbank Protein ID

 AF299337; AF302272; AF302265; AF302266; AF302267; AF302268; AF302269; AF302270; AF302271; AK014042; BC021439 

Genbank Nucleotide ID

 AAG39256.1; AAG32038.1; AAG32038.1; AAG32038.1; AAG32038.1; AAG32038.1; AAG32038.1; AAG32038.1; AAG32038.1; BAB29128.1; AAH21439.1 

Protein Name

 NAD-dependent protein deacetylase sirtuin-2 

Protein Synonyms/Alias

 Regulatory protein SIR2 homolog 2; SIR2-like protein 2; mSIR2L2 

Gene Name

 Sirt2 

Gene Synonyms/Alias

 Sir2l2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	TLGLGSQKERLLDEL	ubiquitination	[1]
126	FEISYFKKHPEPFFA	ubiquitination	[1]
144	ELYPGQFKPTICHYF	ubiquitination	[1]
202	CVNTSCRKEYTMGWM	ubiquitination	[1]
210	EYTMGWMKEKIFSEA	ubiquitination	[1]
287	TPRLLINKEKTGQTD	ubiquitination	[1]
339	ADLLGWKKELEDLVR	ubiquitination	[1]
371	STTISPGKSPPPAKE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA (By similarity). 

Sequence Annotation

 DOMAIN 65 340 Deacetylase sirtuin-type.
 NP_BIND 84 104 NAD (By similarity).
 NP_BIND 167 170 NAD (By similarity).
 NP_BIND 261 263 NAD (By similarity).
 NP_BIND 286 288 NAD (By similarity).
 ACT_SITE 187 187 Proton acceptor (By similarity).
 METAL 195 195 Zinc (By similarity).
 METAL 200 200 Zinc (By similarity).
 METAL 221 221 Zinc (By similarity).
 METAL 224 224 Zinc (By similarity).
 BINDING 324 324 NAD; via amide nitrogen (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 23 23 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Metal-binding; Microtubule; Mitosis; NAD; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 389 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005874; C:microtubule; ISS:UniProtKB.
 GO:0035035; F:histone acetyltransferase binding; ISS:UniProtKB.
 GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0017136; F:NAD-dependent histone deacetylase activity; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0042903; F:tubulin deacetylase activity; ISS:UniProtKB.
 GO:0043130; F:ubiquitin binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0045843; P:negative regulation of striated muscle tissue development; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 

Interpro

 IPR017328; NAD-dep_deAcase_SIR2_class_I.
 IPR003000; Sirtuin.
 IPR026590; Ssirtuin_cat_dom. 

Pfam

 PF02146; SIR2 

SMART

  

PROSITE

 PS50305; SIRTUIN 

PRINTS