| Tag | Content |
|---|
| CPLM ID | CPLM-001648 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Semaphorin-4F |
Protein Synonyms/Alias | Semaphorin-M; Sema M; Semaphorin-W; Sema W |
Gene Name | SEMA4F |
Gene Synonyms/Alias | SEMAM; SEMAW |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 169 | RLESGRGKCPFEPAQ | ubiquitination | [1] | | 390 | ECITNNMKLRHFGSS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). |
Sequence Annotation | DOMAIN 42 510 Sema.
DOMAIN 512 563 PSI.
DOMAIN 580 635 Ig-like C2-type.
CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
CARBOHYD 133 133 N-linked (GlcNAc...) (Potential).
CARBOHYD 509 509 N-linked (GlcNAc...) (Potential).
DISULFID 112 122 By similarity.
DISULFID 140 149 By similarity.
DISULFID 273 384 By similarity.
DISULFID 297 343 By similarity.
DISULFID 513 530 By similarity.
DISULFID 522 539 By similarity.
DISULFID 587 628 By similarity. |
Keyword | Alternative splicing; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 770 AA |
Protein Sequence | MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP 60
HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED 120
ECHNFVQILA IANASHLLTC GTFAFDPKCG VIDVSRFQQV ERLESGRGKC PFEPAQRSAA 180
VMAGGVLYAA TVKNYLGTEP IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD 240
EDGDDEIYFF FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP 300
EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI RTVLNGPFRE 360
LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL PDRVLTFIRD HPLMDRPVFP 420
ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL 480
FPEPQPVENM KLYHSWLLVG SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV 540
AHAGEHRGLV QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ 600
PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR DAPSRAHTVG 660
AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL DLGAPPSGTT SYSQDPPSPS 720
PEDERLPLAL AKRGSGFGGF SPPFLLDPCP SPAHIRLTGA PLATCDETSI 770 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0045211; C:postsynaptic membrane; IEA:Compara. GO:0004872; F:receptor activity; IEA:InterPro. GO:0007411; P:axon guidance; TAS:ProtInc. GO:0007267; P:cell-cell signaling; TAS:ProtInc. GO:0030517; P:negative regulation of axon extension; IEA:Compara. GO:0031290; P:retinal ganglion cell axon guidance; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |