CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005812
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sialidase 
Protein Synonyms/Alias
 N-acylneuraminate glycohydrolase; Neuraminidase; NANase; STNA 
Gene Name
 nanH 
Gene Synonyms/Alias
 STM0928 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
34SGSGGTTKYFRIPAMacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. 
Sequence Annotation
 REPEAT 71 82 BNR 1.
 REPEAT 145 156 BNR 2.
 REPEAT 210 220 BNR 3.
 REPEAT 254 265 BNR 4.
 ACT_SITE 62 62 Proton acceptor (By similarity).
 ACT_SITE 342 342 Nucleophile (By similarity).
 ACT_SITE 361 361
 BINDING 37 37 Substrate.
 BINDING 246 246 Substrate.
 BINDING 309 309 Substrate.
 DISULFID 42 103  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 382 AA 
Protein Sequence
MTVEKSVVFK AEGEHFTDQK GNTIVGSGSG GTTKYFRIPA MCTTSKGTIV VFADARHNTA 60
SDQSFIDTAA ARSTDGGKTW NKKIAIYNDR VNSKLSRVMD PTCIVANIQG RETILVMVGK 120
WNNNDKTWGA YRDKAPDTDW DLVLYKSTDD GVTFSKVETN IHDIVTKNGT ISAMLGGVGS 180
GLQLNDGKLV FPVQMVRTKN ITTVLNTSFI YSTDGITWSL PSGYCEGFGS ENNIIEFNAS 240
LVNNIRNSGL RRSFETKDFG KTWTEFPPMD KKVDNRNHGV QGSTITIPSG NKLVAAHSSA 300
QNKNNDYTRS DISLYAHNLY SGEVKLIDDF YPKVGNASGA GYSCLSYRKN VDKETLYVVY 360
EANGSIEFQD LSRHLPVIKS YN 382 
Gene Ontology
 GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:EC.
 GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:EC.
 GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:EC.
 GO:0009405; P:pathogenesis; IEA:InterPro. 
Interpro
 IPR026948; Sialidase.
 IPR026856; Sialidase_fam.
 IPR008377; Sialidase_trypan.
 IPR011040; Sialidases. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR01803; TCSIALIDASE.