UniProt Accession

 CATC_HUMAN; P53634; A8K7V2; B5MDD5; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8 

Genbank Protein ID

 X87212; U79415; AF234263; AF234264; AF254757; AF525032; AF525033; AK292117; AK311923; AK223038; BX537913; AC011088; CH471185; BC054028; BC100891; BC100892; BC100893; BC100894; BC109386; BC110071; BC113850; BC113897 

Genbank Nucleotide ID

 CAA60671.1; AAC51341.1; AAL48191.1; AAL48192.1; AAL48195.1; AAQ08887.1; AAQ08888.1; BAF84806.1; BAG34864.1; BAD96758.1; CAD97897.1; EAW59364.1; AAH54028.1; AAI00892.1; AAI00893.1; AAI00894.1; AAI00895.1; AAI09387.1; AAI10072.1; AAI13851.1; AAI13898.1 

Protein Name

 Dipeptidyl peptidase 1 

Protein Synonyms/Alias

 Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase; Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase I exclusion domain chain; Dipeptidyl peptidase 1 heavy chain; Dipeptidyl peptidase I heavy chain; Dipeptidyl peptidase 1 light chain; Dipeptidyl peptidase I light chain 

Gene Name

 CTSC 

Gene Synonyms/Alias

 CPPI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
141	WACFTGKKVGTASEN	ubiquitination	[1]
169	KYSNRLYKYDHNFVK	ubiquitination	[1]
334	TDSPCKMKEDCFRYY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. 

Sequence Annotation

 ACT_SITE 258 258
 ACT_SITE 405 405
 ACT_SITE 427 427
 BINDING 302 302 Chloride.
 BINDING 304 304 Chloride; via amide nitrogen.
 BINDING 347 347 Chloride.
 CARBOHYD 29 29 N-linked (GlcNAc...).
 CARBOHYD 53 53 N-linked (GlcNAc...).
 CARBOHYD 119 119 N-linked (GlcNAc...).
 CARBOHYD 276 276 N-linked (GlcNAc...).
 DISULFID 30 118
 DISULFID 54 136
 DISULFID 255 298
 DISULFID 291 331
 DISULFID 321 337  

Keyword

 3D-structure; Alternative splicing; Chloride; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Palmoplantar keratoderma; Polymorphism; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005764; C:lysosome; TAS:UniProtKB.
 GO:0031404; F:chloride ion binding; IEA:Compara.
 GO:0008234; F:cysteine-type peptidase activity; IDA:UniProtKB.
 GO:0004252; F:serine-type endopeptidase activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0006508; P:proteolysis; IDA:UniProtKB.
 GO:0010033; P:response to organic substance; IEA:Compara.
 GO:0001913; P:T cell mediated cytotoxicity; IEA:Compara. 

Interpro

 IPR014882; CathepsinC_exc.
 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C. 

Pfam

 PF08773; CathepsinC_exc
 PF00112; Peptidase_C1 

SMART

 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.