CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002528
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myelin-associated glycoprotein 
Protein Synonyms/Alias
 Brain neuron cytoplasmic protein 3; Sialic acid-binding Ig-like lectin 4a; Siglec-4a 
Gene Name
 Mag 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
570RISGAPDKYESEKRLacetylation[1]
570RISGAPDKYESEKRLubiquitination[2]
575PDKYESEKRLGSERRubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity). 
Sequence Annotation
 DOMAIN 22 120 Ig-like V-type.
 DOMAIN 139 237 Ig-like C2-type 1.
 DOMAIN 241 325 Ig-like C2-type 2.
 DOMAIN 327 412 Ig-like C2-type 3.
 DOMAIN 413 508 Ig-like C2-type 4.
 BINDING 118 118 Sialic acid (By similarity).
 LIPID 531 531 S-palmitoyl cysteine.
 CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
 CARBOHYD 223 223 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 332 332 N-linked (GlcNAc...) (Potential).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 450 450 N-linked (GlcNAc...) (Potential).
 CARBOHYD 454 454 N-linked (GlcNAc...) (Potential).
 DISULFID 37 165 Probable.
 DISULFID 42 100 Probable.
 DISULFID 159 217 Probable.
 DISULFID 261 305 Probable.
 DISULFID 347 392 Probable.
 DISULFID 421 430 Probable.
 DISULFID 432 488 Probable.  
Keyword
 Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Lipoprotein; Membrane; Palmitate; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 626 AA 
Protein Sequence
MIFLTTLPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY 60
FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSTLSPE LGGKYYFRGD 120
LGGYNQYTFS EHSVLDIINT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL 180
GEPTVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAA FPNTTLQFEG YASLDVKYPP 240
VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGMVL REAVAESLYL DLEEVTPAED 300
GIYACLAENA YGQDNRTVEL SVMYAPWKPT VNGTVVAVEG ETVSILCSTQ SNPDPILTIF 360
KEKQILATVI YESQLQLELP AVTPEDDGEY WCVAENQYGQ RATAFNLSVE FAPIILLESH 420
CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNETEREF VYSERSGLLL TSILTLRGQA 480
QAPPRVICTS RNLYGTQSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK 540
NVTESPSFSA GDNPHVLYSP EFRISGAPDK YESEKRLGSE RRLLGLRGEP PELDLSYSHS 600
DLGKRPTKDS YTLTEELAEY AEIRVK 626 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033270; C:paranode region of axon; IEA:Compara.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF08205; C2-set_2
 PF07679; I-set 
SMART
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS