UniProt Accession

 FIS1_RAT; P84817; B2RZ80; D4A5K3 

Genbank Protein ID

 AC111745; CH473973; BC167057 

Genbank Nucleotide ID

 EDM13301.1; AAI67057.1 

Protein Name

 Mitochondrial fission 1 protein 

Protein Synonyms/Alias

 FIS1 homolog; rFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11 

Gene Name

 Fis1 

Gene Synonyms/Alias

 Ttc11 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
46	AWCLVRSKYNDDIRR	acetylation	[1]
89	YRLKEYEKALKYVRG	acetylation	[1]
92	KEYEKALKYVRGLLQ	acetylation	[1]
108	EPQNNQAKELERLID	acetylation	[1]
108	EPQNNQAKELERLID	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. 

Sequence Annotation

 REPEAT 71 104 TPR.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Apoptosis; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Peroxisome; Reference proteome; TPR repeat; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; ISS:UniProtKB.
 GO:0005779; C:integral to peroxisomal membrane; ISS:UniProtKB.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IEA:Compara.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; ISS:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IEA:Compara.
 GO:0070584; P:mitochondrion morphogenesis; IEA:Compara.
 GO:0016559; P:peroxisome fission; ISS:UniProtKB.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IEA:Compara.
 GO:0010821; P:regulation of mitochondrion organization; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara. 

Interpro

 IPR016543; Tetratricopeptide_rpt_11_Fis1.
 IPR011990; TPR-like_helical. 

Pfam

  

SMART

  

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS