UniProt Accession

 RAB10_MOUSE; P61027; O88386; Q9D7X6 

Genbank Protein ID

 AF035646; AK008725; AK028320; AK087964; BC056374 

Genbank Nucleotide ID

 AAC29313.1; BAB25858.1; BAC25878.1; BAC40062.1; AAH56374.1 

Protein Name

 Ras-related protein Rab-10 

Protein Synonyms/Alias

  

Gene Name

 Rab10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
102	KSFENISKWLRNIDE	acetylation	[1]
102	KSFENISKWLRNIDE	ubiquitination	[2]
154	RFFETSAKANINIEK	ubiquitination	[2]
177	ILRKTPVKEPNSENV	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. Finally, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. 

Sequence Annotation

 NP_BIND 16 23 GTP (By similarity).
 NP_BIND 64 68 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 MOTIF 38 46 Effector region (By similarity).
 MOD_RES 102 102 N6-acetyllysine (By similarity).
 LIPID 199 199 S-geranylgeranyl cysteine (By
 LIPID 200 200 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Cell projection; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endoplasmic reticulum; Endosome; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0071782; C:endoplasmic reticulum tubular network; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0032593; C:insulin-responsive compartment; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0072372; C:primary cilium; IDA:UniProtKB.
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0007409; P:axonogenesis; ISS:UniProtKB.
 GO:0061467; P:basolateral protein localization; ISS:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; IMP:UniProtKB.
 GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
 GO:0016197; P:endosomal transport; ISS:UniProtKB.
 GO:0045200; P:establishment of neuroblast polarity; ISS:UniProtKB.
 GO:0097051; P:establishment of protein localization to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0043001; P:Golgi to plasma membrane protein transport; ISS:UniProtKB.
 GO:0030859; P:polarized epithelial cell differentiation; ISS:UniProtKB.
 GO:0072659; P:protein localization to plasma membrane; IMP:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.