UniProt Accession

 FADR_ECOLI; P0A8V6; P09371; P76827 

Genbank Protein ID

 X08087; U00096; AP009048 

Genbank Nucleotide ID

 CAA30881.1; AAC74271.1; BAA36042.1 

Protein Name

 Fatty acid metabolism regulator protein 

Protein Synonyms/Alias

  

Gene Name

 fadR 

Gene Synonyms/Alias

 oleR; thdB; b1187; JW1176 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
195	LALGFYHKLSALCSE	acetylation	[1]
228	EIWHRMQKNLPGDLA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds. 

Sequence Annotation

 DOMAIN 6 74 HTH gntR-type.
 DNA_BIND 34 53 H-T-H motif (By similarity).  

Keyword

 3D-structure; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Fatty acid metabolism; Lipid metabolism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:EcoCyc.
 GO:0019395; P:fatty acid oxidation; EXP:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:EcoCyc.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:EcoCyc.
 GO:0019217; P:regulation of fatty acid metabolic process; IEA:HAMAP.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR014178; FA-response_TF_FadR.
 IPR008920; FA-response_TF_FadR_C.
 IPR027376; FadR/GntR_C.
 IPR000524; Tscrpt_reg_HTH_GntR.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF07840; FadR_C
 PF00392; GntR 

SMART

 SM00345; HTH_GNTR 

PROSITE

 PS50949; HTH_GNTR 

PRINTS

 PR00035; HTHGNTR.