CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038667
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Low affinity cationic amino acid transporter 2 
Protein Synonyms/Alias
  
Gene Name
 Slc7a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46LDSLEDSKLCRCLTTubiquitination[1]
243KISEEFLKNISASARubiquitination[1]
465QPKYTPEKETLESCTubiquitination[1]
648INAATEEKSAMQANDubiquitination[1]
670LPFILHEKTSEC***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 674 AA 
Protein Sequence
MASTPSPTLS YRLLSSTMIP CRAVLTFARC LIRRKIVTLD SLEDSKLCRC LTTVDLIALG 60
VGSTLGAGVY VLAGEVAKAD SGPSIVVSFL IAALASVMAG LCYAEFGARV PKTGSAYLYT 120
YVTVGELWAF ITGWNLILSY VIGTSSVARA WSGTFDELLN KQIGQFFKTY FKMNYTGLAE 180
YPDFFAVCLV LLLAGLLSFG VKESAWVNKF FTAINILVLL FVMVAGFVKG NVANWKISEE 240
FLKNISASAR EPPSENGTSI YGAGGFMPYG FTGTLAGAAT CFYAFVGFDC IATTGEEVRN 300
PQKAIPIGIV TSLLVCFMAY FGVSAALTLM MPYYLLDEKS PLPVAFEYVR WSPAKYVVSA 360
GSLCALSTSL LGSMFPLPRI LFAMARDGLL FRFLARVSKR QSPVAATMTA GVISAVMAFL 420
FDLKALVDMM SIGTLMAYSL VAACVLILRY QPGLCYDQPK YTPEKETLES CTNATLKSES 480
QVTMLQGQGF SLRTLFSPSA LPTRQSASLV SFLVGFLAFL ILGLSILTTY GVQAIARLEA 540
WSLALLALFL VLCVAVILTI WRQPQNQQKV AFMVPFLPFL PAFSILVNIY LMVQLSADTW 600
IRFSIWMALG FLIYFAYGIR HSLEGNPRDE EDDEDAFSDN INAATEEKSA MQANDHHQRN 660
LSLPFILHEK TSEC 674 
Gene Ontology
 GO:0016021; C:integral to membrane; IDA:MGI.
 GO:0005289; F:high affinity arginine transmembrane transporter activity; IDA:MGI.
 GO:0015189; F:L-lysine transmembrane transporter activity; IDA:MGI.
 GO:0000064; F:L-ornithine transmembrane transporter activity; IDA:MGI.
 GO:0042116; P:macrophage activation; IMP:MGI.
 GO:0006809; P:nitric oxide biosynthetic process; IMP:MGI.
 GO:0002537; P:nitric oxide production involved in inflammatory response; IMP:MGI.
 GO:0050727; P:regulation of inflammatory response; IMP:MGI. 
Interpro
 IPR002293; AA/rel_permease1.
 IPR015606; Cat-AATrans.
 IPR004755; Cat_AA_permease. 
Pfam
  
SMART
  
PROSITE
  
PRINTS