| Tag | Content |
|---|
| CPLM ID | CPLM-015365 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Reticulon-3 |
Protein Synonyms/Alias | |
Gene Name | Rtn3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 921 | GIARDQTKSIVEKIQ | acetylation | [1] | | 926 | QTKSIVEKIQAKLPG | acetylation | [1] | | 936 | AKLPGIAKKKAE*** | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity). |
Sequence Annotation | DOMAIN 752 940 Reticulon.
REGION 895 940 Interaction with FADD (By similarity).
REGION 908 910 Interaction with BACE1 (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 209 209 Phosphoserine (By similarity).
MOD_RES 503 503 Phosphothreonine (By similarity).
MOD_RES 505 505 Phosphothreonine (By similarity).
MOD_RES 575 575 Phosphoserine (By similarity).
MOD_RES 576 576 Phosphoserine (By similarity).
MOD_RES 652 652 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Apoptosis; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 940 AA |
Protein Sequence | MAESSAATQS PSVSSSSSGA EPSTLGGGGG SPGACPALGA KSCGSSCAVG LSSLCSDEPP 60
SKIMTSSFLS SSEIYNPDPT TPLGSETLGS HLVAKDGKDP LVLLDKKTLD SPQGTNKDRV 120
DTPVSLAADI PCSHPSIPDS FPEQPTFLSK ETDPTEEWVV KNQEPKNPSE VPSGEDRSAL 180
DLGQRKAEHI CTHSLSPSEP AVASVEKDSP ESPFEVIIDK ATFDREFKDL YKESTDDLGG 240
WAAHGDRESP ADLLEMNDKV FPLRNKEAGR YPSSALLGRQ FSHTTAALEE VSRCVNDMHN 300
FTNEILTWDL DPQAKQQADK SPCTTESTGL DRSEHRSEIP VINLKTSPQQ KMPVCSFNGS 360
TPITRSTGDW TETFTEGKPV KGYLSSTKEA GGKGVPDSSQ PISGSGAATV EVTLPDLRGT 420
WPNSVLGEVT EVDSSGESDD TVIEDTTENP SVKNNKVLPE KSDSLPSAAV KTSERENKET 480
TSHETVRSEM YENSEQQQAH AETPTQRSLE GQMSPQVPNM LNEVIPENLA MTDTTRVCSA 540
APPSVLSETG FSLTVPASAK SESLLGKNVE DTDGSSPEDL MAALTGTEEK GTVDKEKGDV 600
LEAVLEKIAN VKNTLPVELL HENKLSSSET KNTKSKYSEH SRETNGGAPK VSSDLEQEQL 660
TIRAIKELGA KQVQAERMSP GGKLKRTFDP QSGPQNSSDI LEHTDITTGS DLGIPKKPTI 720
IKDTRIDSIS SLTKTETVNK HVLARLLSDF PVHDLIFWRD VKKTGFVFGT TLIMLLSLAA 780
FSVISVVSYL ILALLSVTIS FRVYKSVIQA VQKSEEGHPF KAYLDVDITL SSEAFHSYMN 840
AAMVHVNKAL KLIIRLFLVE DLVDSLKLAV FMWLMTYVGA VFNGITLLIL AELLVFSVPI 900
VYEKYKTQID HYVGIARDQT KSIVEKIQAK LPGIAKKKAE 940 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0071786; P:endoplasmic reticulum tubular network organization; IEA:Compara. GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |