UniProt Accession

 X3CL1_RAT; O55145 

Genbank Protein ID

 AF030358; Y16813 

Genbank Nucleotide ID

 AAC33834.2; CAA76404.1 

Protein Name

 Fractalkine 

Protein Synonyms/Alias

 C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; Processed fractalkine 

Gene Name

 Cx3cl1 

Gene Synonyms/Alias

 Acc1; Fkn; Scyd1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
367	SLQGCPRKMAGEMVE	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. 

Sequence Annotation

 REGION 25 100 Chemokine.
 REGION 101 337 Mucin-like stalk.
 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 DISULFID 32 58 By similarity.
 DISULFID 36 74 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Chemotaxis; Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IDA:RGD.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008009; F:chemokine activity; IDA:RGD.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0006935; P:chemotaxis; IDA:RGD.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0050710; P:negative regulation of cytokine secretion; IMP:RGD.
 GO:0045906; P:negative regulation of vasoconstriction; IDA:RGD.
 GO:0030168; P:platelet activation; IMP:RGD.
 GO:0045785; P:positive regulation of cell adhesion; IDA:RGD.
 GO:0010759; P:positive regulation of macrophage chemotaxis; IMP:RGD.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:RGD.
 GO:0060080; P:regulation of inhibitory postsynaptic membrane potential; IMP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD. 

Interpro

 IPR008097; Chemokine_CX3CL1.
 IPR001811; Chemokine_IL8-like_dom. 

Pfam

 PF00048; IL8 

SMART

 SM00199; SCY 

PROSITE

  

PRINTS

 PR01721; FRACTALKINE.