| Tag | Content |
|---|
| CPLM ID | CPLM-004130 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interleukin-1 receptor type 1 |
Protein Synonyms/Alias | IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD121a; Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI |
Gene Name | Il1r1 |
Gene Synonyms/Alias | Il-1r1; Il1ra |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 501 | EKIQDYEKMPDSIQF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity). |
Sequence Annotation | DOMAIN 25 115 Ig-like C2-type 1.
DOMAIN 121 213 Ig-like C2-type 2.
DOMAIN 229 329 Ig-like C2-type 3.
DOMAIN 386 544 TIR.
MOD_RES 499 499 Phosphotyrosine (By similarity).
MOD_RES 556 556 Phosphothreonine; by PKC.
CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).
CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).
CARBOHYD 252 252 N-linked (GlcNAc...) (Potential).
CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
CARBOHYD 300 300 N-linked (GlcNAc...) (Potential).
DISULFID 25 107 By similarity.
DISULFID 46 99 By similarity.
DISULFID 145 199 By similarity.
DISULFID 251 315 By similarity. |
Keyword | 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 576 AA |
Protein Sequence | MENMKVLLGL ICLMVPLLSL EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP NKMHGDTIIW 60
YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI VRNSTYCLKT KVTVTVLEND 120
PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY FKDENNELPE VQWYKNCKPL LLDNVSFFGV 180
KDKLLVRNVA EEHRGDYICR MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE 240
ADPGSMIQLI CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN 300
ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFKNY LIGGFIILTA TIVCCVCIYK 360
VFKVDIVLWY RDSCSGFLPS KASDGKTYDA YILYPKTLGE GSFSDLDTFV FKLLPEVLEG 420
QFGYKLFIYG RDDYVGEDTI EVTNENVKKS RRLIIILVRD MGGFSWLGQS SEEQIAIYNA 480
LIQEGIKIVL LELEKIQDYE KMPDSIQFIK QKHGVICWSG DFQERPQSAK TRFWKNLRYQ 540
MPAQRRSPLS KHRLLTLDPV RDTKEKLPAA THLPLG 576 |
Gene Ontology | GO:0009986; C:cell surface; IDA:UniProtKB. GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004908; F:interleukin-1 receptor activity; IDA:MGI. GO:0004909; F:interleukin-1, Type I, activating receptor activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |