UniProt Accession

 UPAR_HUMAN; Q03405; A8K409; Q12876; Q15845; Q16887; Q6IB52; Q9BWT0; Q9NYC8; Q9UD69; Q9UEA6; Q9UM92; Q9UMV0 

Genbank Protein ID

 X51675; M83246; X74039; U09346; U09347; U08839; U09937; U09931; U09932; U09933; U09935; U09936; AY194849; AK290774; CR456952; AC005525; AC006953; AC006953; CH471126; BC002788; AF257789; AY029180; S78532 

Genbank Nucleotide ID

 CAA35981.1; AAA59862.1; CAA52191.1; AAA17979.1; AAA17978.1; AAB60333.1; AAB60690.1; AAB60690.1; AAB60690.1; AAB60690.1; AAB60690.1; AAB60690.1; AAN86351.1; BAF83463.1; CAG33233.1; AAC32739.1; AAD17387.1; AAD17388.1; EAW57220.1; AAH02788.1; AAF71751.1; AAK31795.1; AAD14289.1 

Protein Name

 Urokinase plasminogen activator surface receptor 

Protein Synonyms/Alias

 U-PAR; uPAR; Monocyte activation antigen Mo3; CD87 

Gene Name

 PLAUR 

Gene Synonyms/Alias

 MO3; UPAR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
254	ATGTHEPKNQSYMVR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. 

Sequence Annotation

 DOMAIN 23 114 UPAR/Ly6 1.
 DOMAIN 115 213 UPAR/Ly6 2.
 DOMAIN 214 305 UPAR/Ly6 3.
 LIPID 305 305 GPI-anchor amidated glycine (Probable).
 CARBOHYD 74 74 N-linked (GlcNAc...).
 CARBOHYD 184 184 N-linked (GlcNAc...).
 CARBOHYD 194 194 N-linked (GlcNAc...).
 CARBOHYD 222 222 N-linked (GlcNAc...).
 CARBOHYD 255 255 N-linked (GlcNAc...).
 DISULFID 25 46
 DISULFID 28 34
 DISULFID 39 67
 DISULFID 93 98
 DISULFID 117 144
 DISULFID 120 127
 DISULFID 137 169
 DISULFID 175 192
 DISULFID 193 198
 DISULFID 216 244
 DISULFID 219 227
 DISULFID 237 263
 DISULFID 269 287
 DISULFID 288 293  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; TAS:ProtInc.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0030377; F:U-plasminogen activator receptor activity; NAS:UniProtKB.
 GO:0016255; P:attachment of GPI anchor to protein; TAS:Reactome.
 GO:0007596; P:blood coagulation; NAS:UniProtKB.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0006928; P:cellular component movement; NAS:UniProtKB.
 GO:0006935; P:chemotaxis; TAS:ProtInc.
 GO:0042730; P:fibrinolysis; TAS:Reactome.
 GO:0030162; P:regulation of proteolysis; NAS:UniProtKB. 

Interpro

 IPR018363; CD59_antigen_CS.
 IPR016054; LY6_UPA_recep-like.
 IPR001526; LY6_UPAR. 

Pfam

 PF00021; UPAR_LY6 

SMART

 SM00134; LU 

PROSITE

 PS00983; LY6_UPAR 

PRINTS