UniProt Accession

 IL1AP_MOUSE; Q61730; Q8VCB9 

Genbank Protein ID

 X85999; AK039582; AK045686; BC021159 

Genbank Nucleotide ID

 CAA59991.1; BAC30392.1; BAC32457.1; AAH21159.1 

Protein Name

 Interleukin-1 receptor accessory protein 

Protein Synonyms/Alias

 IL-1 receptor accessory protein; IL-1RAcP 

Gene Name

 Il1rap 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
559	PRWSSNDKQGLSYSS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). 

Sequence Annotation

 DOMAIN 21 128 Ig-like C2-type 1.
 DOMAIN 139 230 Ig-like C2-type 2.
 DOMAIN 243 348 Ig-like C2-type 3.
 DOMAIN 403 549 TIR.
 MOD_RES 395 395 Phosphothreonine.
 MOD_RES 398 398 Phosphothreonine.
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
 CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
 CARBOHYD 118 118 N-linked (GlcNAc...) (Potential).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
 CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
 CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
 DISULFID 24 122 By similarity.
 DISULFID 47 114 By similarity.
 DISULFID 137 181 By similarity.
 DISULFID 160 212 By similarity.
 DISULFID 266 332 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 570 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004908; F:interleukin-1 receptor activity; IDA:MGI.
 GO:0042094; P:interleukin-2 biosynthetic process; IDA:MGI. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR015621; IL1-receptor_fam.
 IPR004074; IL1_rcpt_I/II.
 IPR000157; TIR_dom. 

Pfam

 PF01582; TIR 

SMART

 SM00409; IG
 SM00255; TIR 

PROSITE

 PS50835; IG_LIKE
 PS50104; TIR 

PRINTS

 PR01536; INTRLKN1R12F.