CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012536
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 41 
Protein Synonyms/Alias
 Protein Muf1 
Gene Name
 LRRC41 
Gene Synonyms/Alias
 MUF1; PP7759 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34SREAAPAKSSASGPNubiquitination[1]
95IEETALKKGLSTQAIubiquitination[1]
199ASSLHTLKFRHLLFSubiquitination[2, 3, 4, 5, 6, 7]
339TAGGTDLKRELHPPAubiquitination[1, 3, 5, 7, 8, 9]
375SSSTSSYKRAPASSAubiquitination[2, 3, 4, 5, 6, 8]
705MKGNSTLKGLRLPGNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [9] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
 Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 
Sequence Annotation
 REPEAT 487 507 LRR 1.
 REPEAT 518 530 LRR 2.
 REPEAT 531 555 LRR 3.
 REPEAT 613 635 LRR 4.
 REPEAT 636 659 LRR 5.
 REPEAT 701 728 LRR 6.
 REPEAT 731 752 LRR 7.
 REGION 45 54 Interaction with Elongin BC complex (By
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 327 327 Phosphothreonine.
 MOD_RES 357 357 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 812 AA 
Protein Sequence
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC GRAVSAHMGV 60
LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES 120
VTCWRAKFME AFFSHVLRGT IDVSSDRRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV 180
AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES 240
ALFILILTMS AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA 300
LMASRRKSEA KQMPRAAPAT RVTRRSTQES LTAGGTDLKR ELHPPATSHE APGTKRSPSA 360
PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA RTRQGPGAES EDLYDFVFIV 420
AGEKEDGEEM EIGEVACGAL DGSDPSCLGL PALEASQRFR SISTLELFTV PLSTEAALTL 480
CHLLSSWVSL ESLTLSYNGL GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT 540
RAIVRALPLL RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA 600
QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS FHDMNLADCQ 660
SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG NSTLKGLRLP GNRLGNAGLL 720
ALADVFSEDS SSSLCQLDIS SNCIKPDGLL EFAKRLERWG RGAFGHLRLF QNWLDQDAVT 780
AREAIRRLRA TCHVVSDSWD SSQAFADYVS TM 812 
Gene Ontology
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
 IPR026137; Leu_rpt_41. 
Pfam
  
SMART
  
PROSITE
  
PRINTS