CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040153
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal-induced proliferation-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 SIPA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
294PRGLSPRKLLEHVAPubiquitination[1]
316RLGSASPKVPRTLLTubiquitination[1]
334QVLSFQRKVGILYCRubiquitination[1]
510FRAFLLAKALNGEQAubiquitination[1]
930TRLLLASKQLGSPTAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 940 AA 
Protein Sequence
MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL LRSGSDAGEA 60
RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA EEPEPAFPPV LEPRWFAHYD 120
VQSLLFDWAP RSQGMGSHSE ASSGTLASAE DQAASSDLLH GAPGFVCELG GEGELGLGGP 180
ASPPVPPALP NAAVSILEEP QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP 240
VAVSLRREEK EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA 300
PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM YNNQEAGPAF 360
MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ DHEIMFHVST MLPYTPNNQQ 420
QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT 480
QDTPAFGPAL PAGGGPFAAN ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA 540
TNEQLDLYHG RGEAITLRFD GSPGQAVGEV VARLQLVSRG CETRELALPR DGQGRLGFEV 600
DAEGFVTHVE RFTFAETAGL RPGARLLRVC GQTLPSLRPE AAAQLLRSAP KVCVTVLPPD 660
ESGRPRRSFS ELYTLSLQEP SRRGAPDPVQ DEVQGVTLLP TTKQLLHLCL QDGGSPPGPG 720
DLAEERTEFL HSQNSLSPRS SLSDEAPVLP NTTPDLLLAT TAKPSVPSAD SETPLTQDRP 780
GSPSGSEDKG NPAPELRASF LPRTLSLRNS ISRIMSEAGS GTLEDEWQAI SEIASTCNTI 840
LESLSREGQP IPESGDPKGT PKSDAEPEPG NLSEKVSHLE SMLRKLQEDL QKEKADRAAL 900
EEEVRSLRHN NRRLQAESES AATRLLLASK QLGSPTADLA 940 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR001478; PDZ.
 IPR000331; Rap_GAP_dom. 
Pfam
 PF00595; PDZ
 PF02145; Rap_GAP 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ
 PS50085; RAPGAP 
PRINTS