| Tag | Content |
|---|
| CPLM ID | CPLM-016965 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Epidermal growth factor-like protein 6 |
Protein Synonyms/Alias | EGF-like protein 6; MAM and EGF domains-containing gene protein |
Gene Name | EGFL6 |
Gene Synonyms/Alias | MAEG; PP648; UNQ281/PRO320 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 332 | GGNSHGGKKGNEEKM | acetylation | [1] | | 333 | GNSHGGKKGNEEKMK | acetylation | [1] | | 338 | GKKGNEEKMKEGLED | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). |
Sequence Annotation | DOMAIN 65 91 EGF-like 1.
DOMAIN 94 133 EGF-like 2; calcium-binding (Potential).
DOMAIN 137 173 EGF-like 3.
DOMAIN 174 212 EGF-like 4; calcium-binding (Potential).
DOMAIN 219 259 EGF-like 5; calcium-binding (Potential).
DOMAIN 400 546 MAM.
CARBOHYD 397 397 N-linked (GlcNAc...) (Potential).
DISULFID 98 109 By similarity.
DISULFID 105 118 By similarity.
DISULFID 120 132 By similarity.
DISULFID 178 191 By similarity.
DISULFID 185 200 By similarity.
DISULFID 223 236 By similarity.
DISULFID 230 245 By similarity.
DISULFID 247 258 By similarity. |
Keyword | Alternative splicing; Basement membrane; Calcium; Cell adhesion; Coiled coil; Complete proteome; Developmental protein; Differentiation; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MPLPWSLALP LLLSWVAGGF GNAASARHHG LLASARQPGV CHYGTKLACC YGWRRNSKGV 60
CEATCEPGCK FGECVGPNKC RCFPGYTGKT CSQDVNECGM KPRPCQHRCV NTHGSYKCFC 120
LSGHMLMPDA TCVNSRTCAM INCQYSCEDT EEGPQCLCPS SGLRLAPNGR DCLDIDECAS 180
GKVICPYNRR CVNTFGSYYC KCHIGFELQY ISGRYDCIDI NECTMDSHTC SHHANCFNTQ 240
GSFKCKCKQG YKGNGLRCSA IPENSVKEVL RAPGTIKDRI KKLLAHKNSM KKKAKIKNVT 300
PEPTRTPTPK VNLQPFNYEE IVSRGGNSHG GKKGNEEKMK EGLEDEKREE KALKNDIEER 360
SLRGDVFFPK VNEAGEFGLI LVQRKALTSK LEHKDLNISV DCSFNHGICD WKQDREDDFD 420
WNPADRDNAI GFYMAVPALA GHKKDIGRLK LLLPDLQPQS NFCLLFDYRL AGDKVGKLRV 480
FVKNSNNALA WEKTTSEDEK WKTGKIQLYQ GTDATKSIIF EAERGKGKTG EIAVDGVLLV 540
SGLCPDSLLS VDD 553 |
Gene Ontology | GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell. GO:0005615; C:extracellular space; TAS:ProtInc. GO:0016020; C:membrane; IEA:InterPro. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005178; F:integrin binding; TAS:ProtInc. GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. GO:0007049; P:cell cycle; TAS:ProtInc. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0030198; P:extracellular matrix organization; IEA:Compara. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |