CPLM-018066

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018066

UniProt Accession

DEN1A_HUMAN; Q8TEH3; A8MZA3; B1AM80; B7Z3C8; B7Z669; D3PFD3; Q05C88; Q5VWF0; Q6PJZ5; Q8IVD6; Q9H796

Genbank Protein ID

AK024782; AK074151; AK295710; AK299867; AL445489; AL161790; AL390774; AC006450; AL445489; AC006450; AL390774; AL161790; AL390774; AC006450; AL161790; AL445489; AL161790; AC006450; AL445489; AL390774; AL161790; AC006450; AL390774; AL445489; AL161790; AC006450; AL390774; AL445489; AL390774; AC006450; AL445489; AL161790; AL390774; AC006450; AL445489; AL161790; AL445489; AC006450; AL161790; AL390774; CH471090; CH471090; BC009616; BC028061; BC039703; BK006958

Genbank Nucleotide ID

BAB15002.1; BAB84977.1; BAH12164.1; BAH13155.1; CAI39791.1; CAI39791.1; CAI39791.1; CAI39791.1; CAI39792.1; CAI39792.1; CAI39792.1; CAI39792.1; CAH73640.1; CAH73640.1; CAH73640.1; CAH73640.1; CAI15705.1; CAI15705.1; CAI15705.1; CAI15705.1; CAI15706.1; CAI15706.1; CAI15706.1; CAI15706.1; CAI15707.1; CAI15707.1; CAI15707.1; CAI15707.1; CAH73637.1; CAH73637.1; CAH73637.1; CAH73637.1; CAH73638.1; CAH73638.1; CAH73638.1; CAH73638.1; CAI39794.1; CAI39794.1; CAI39794.1; CAI39794.1; EAW87571.1; EAW87575.1; AAH09616.1; AAH28061.1; AAH39703.1; DAA12500.1

Protein Name

DENN domain-containing protein 1A

Protein Synonyms/Alias

Connecdenn 1; Connecdenn; Protein FAM31A

Gene Name

DENND1A

Gene Synonyms/Alias

FAM31A; KIAA1608

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
299	SLKNRLKKVSTTTGD	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles.

Sequence Annotation

DOMAIN 24 91 UDENN.
DOMAIN 92 273 DENN.
DOMAIN 304 371 dDENN.
MOD_RES 519 519 Phosphothreonine.
MOD_RES 520 520 Phosphoserine.
MOD_RES 523 523 Phosphoserine.
MOD_RES 536 536 Phosphoserine.
MOD_RES 538 538 Phosphoserine.
MOD_RES 546 546 Phosphoserine.
MOD_RES 592 592 Phosphoserine.

Keyword

Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasmic vesicle; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Protein transport; Reference proteome; Synapse; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1009 AA

Protein Sequence

MGSRIKQNPE TTFEVYVEVA YPRTGGTLSD PEVQRQFPED YSDQEVLQTL TKFCFPFYVD 60
SLTVSQVGQN FTFVLTDIDS KQRFGFCRLS SGAKSCFCIL SYLPWFEVFY KLLNILADYT 120
TKRQENQWNE LLETLHKLPI PDPGVSVHLS VHSYFTVPDT RELPSIPENR NLTEYFVAVD 180
VNNMLHLYAS MLYERRILII CSKLSTLTAC IHGSAAMLYP MYWQHVYIPV LPPHLLDYCC 240
APMPYLIGIH LSLMEKVRNM ALDDVVILNV DTNTLETPFD DLQSLPNDVI SSLKNRLKKV 300
STTTGDGVAR AFLKAQAAFF GSYRNALKIE PEEPITFCEE AFVSHYRSGA MRQFLQNATQ 360
LQLFKQFIDG RLDLLNSGEG FSDVFEEEIN MGEYAGSDKL YHQWLSTVRK GSGAILNTVK 420
TKANPAMKTV YKFAKDHAKM GIKEVKNRLK QKDIAENGCA PTPEEQLPKT APSPLVEAKD 480
PKLREDRRPI TVHFGQVRPP RPHVVKRPKS NIAVEGRRTS VPSPEQPQPY RTLRESDSAE 540
GDEAESPEQQ VRKSTGPVPA PPDRAASIDL LEDVFSNLDM EAALQPLGQA KSLEDLRAPK 600
DLREQPGTFD YQRLDLGGSE RSRGVTVALK LTHPYNKLWS LGQDDMAIPS KPPAASPEKP 660
SALLGNSLAL PRRPQNRDSI LNPSDKEEVP TPTLGSITIP RPQGRKTPEL GIVPPPPIPR 720
PAKLQAAGAA LGDVSERLQT DRDRRAALSP GLLPGVVPQG PTELLQPLSP GPGAAGTSSD 780
ALLALLDPLS TAWSGSTLPS RPATPNVATP FTPQFSFPPA GTPTPFPQPP LNPFVPSMPA 840
APPTLPLVST PAGPFGAPPA SLGPAFASGL LLSSAGFCAP HRSQPNLSAL SMPNLFGQMP 900
MGTHTSPLQP LGPPAVAPSR IRTLPLARSS ARAAETKQGL ALRPGDPPLL PPRPPQGLEP 960
TLQPSAPQQA RDPFEDLLQK TKQDVSPSPA LAPAPDSVEQ LRKQWETFE 1009

Gene Ontology

GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.
GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
GO:0030425; C:dendrite; IEA:Compara.
GO:0043025; C:neuronal cell body; IEA:Compara.
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0006897; P:endocytosis; IMP:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:0048488; P:synaptic vesicle endocytosis; IEA:Compara.

Interpro

IPR005112; dDENN_dom.
IPR001194; DENN_dom.
IPR005113; uDENN_dom.

Pfam

PF03455; dDENN
PF02141; DENN
PF03456; uDENN

SMART

SM00801; dDENN
SM00799; DENN
SM00800; uDENN

PROSITE

PS50947; DDENN
PS50211; DENN
PS50946; UDENN

PRINTS