CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038649
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Helz2 
Protein Synonyms/Alias
  
Gene Name
 Helz2 
Gene Synonyms/Alias
 BC006779 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
273YPLFGENKWKASPNPubiquitination[1]
356VCIKAHSKQELQEWVubiquitination[1]
594NYRQRMHKFLYEEEAubiquitination[1]
766FRGNHKQKLAVGLIAubiquitination[1]
1016NPIQASGKVPRHPQHubiquitination[1]
1222RGPETEQKSMAQGPQubiquitination[1]
1336VVCSAPQKAREYTNLubiquitination[1]
1465KIFVAEMKDPQQVPIubiquitination[1]
1551PDPASVSKALQRYRSubiquitination[1]
1674EKGGGQIKSLRFAPSubiquitination[1]
1801QQLDSVFKKYRGLVPubiquitination[1]
2067MKLLMLLKEQRWPEIubiquitination[1]
2333FTVEVLSKQLPDLRKubiquitination[1]
2463AVRSALQKQFTVIQGubiquitination[1]
2564SNRSLFGKTSQEGRPubiquitination[1]
2680CFSKTVEKVVLLGDHubiquitination[1]
2688VVLLGDHKQLRPVVKubiquitination[1]
2741SVEFYGGKLKTWSDLubiquitination[1]
2803TQVVRIIKQLTLDRTubiquitination[1]
2936HSLVSAEKVRVQRKSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2947 AA 
Protein Sequence
MASVGCSLRS ASTSATNGPS LAGLCAKVDL YLGCSRCTQC LNESTYILRE VEHTCPREIL 60
LARFKQAAES KIWRKVGRRP SFPTPMRYQV CHYYRPGLGC RRHWNRCTFA RSPEEALVWT 120
FELKNNLPRL KLKEAVQGTR APDRLQTPAD TIRAEFGGHF QLLCAICFTC CPPCLCPVDP 180
RGHCPKHQIC PTLLIHVIVE GLKRQFVEVR PLPQRRHPLN YCMYVGRGVP CRHGASRCEY 240
AHSAVEMAVW KAEQLDGLQR GDLLTYPLFG ENKWKASPNP NPPVTKLYCH ACLVTCNSQE 300
AFENHCSSLE HAQMVAFDQA VPWKHRAPPM GLSKFDLCPR PDLCEHGEVC IKAHSKQELQ 360
EWVQRAQDME LREQAAWQDG LVPYQARLLA EYQRSSKEVS VMAETIRGVS VTCHPPPVHQ 420
AQEKIQHQWV FTIHSEDPLL HVALLNQEPG AAFSLVAPSL PPHQLYAQGK HFCVQSSPAQ 480
YKVGVLVQAV AFGSFEQWVV FDFGRRPVLL QKLKLQLGQT HSQGLNGKPA PSHPQELECW 540
HTGNRHVVLE VDWTPEQEAL MAKYKLPSLA LEFNQIVPDW GPISRSNYRQ RMHKFLYEEE 600
AAQQQLVAKL AMKGQVSLKT ALETPALGML FAPPGALYAK VPFHSSLLPD TDQGFLLSRA 660
VSTALVAPVP APNSTVYQVR LEARASSDHA LWLLLPARCC MALGLQAQDS PILEVQFQID 720
PMTFRFWHQA VDALLEEHLV VPDLPACTLP HPWPTPPSFR GNHKQKLAVG LIAGRRPEGT 780
KHIPPLLIYG PFGTGKTYTL AMAALEVVQQ PHTKVLICTH TNSAADIYIR EYFHDYVSSG 840
HPEATPLRVM YADRPPRQTD PTTLQYCCLT EDRQAFRPPT GPELVHHRLV VTTTSQAREL 900
QVPAGFFSHI FIDEAAQMLE CEALIPLSYA LSLTRVVLAG DHMQVTPRLF SVPRDKSARH 960
TLLHRLFLYY QQEAHKIAQQ SRIIFHENYR STAAIINFVS HHFYLAKGNP IQASGKVPRH 1020
PQHYPLMFCH VAGSPEQDMS MTSWLNSAEV TQVVEKVREI YNTWPHCWGP REQRHICAVS 1080
HGAQVSALRQ ELRRRNLGEV SVGSFEILPG REFRVVVLSS VHNRNSLLSP GAPTSEFFTE 1140
PRVLNTVMTR AQSQLVAVGD AVALCSSGAC RNLWRSFIRE CIEHHSAFPE ELSLEQIEQG 1200
VAQRQNWASL TLKARGPETE QKSMAQGPQR LIAEGTMVTV KAETRAEAAA KAQTAAVAAE 1260
DTASGNSASR DAAAEVSTLE GGMSEEDSES DFWPSDWELN ADDAILKELL DESQQVTVTV 1320
REDGLLDTVV CSAPQKAREY TNLPSSVLWK FLRSNSKQFR RCSFLQETFE RALATPLDDM 1380
ASSPIQVRGR LNCGMAFTGD EVLVQILGPA GDDRCVPGSL QGRVMGVLKR RRHELAFVCR 1440
MDEWDPRIMI PINGSVTKIF VAEMKDPQQV PIHRLIQGQV QRVRHETLKP EDRSTRLFWV 1500
RIVLWRERFY YPLGIVLEVL PKAITWEQGL YILDLEHGLK AHTPDPASVS KALQRYRSEL 1560
NTAAGHREDY RHFLTFTVDP QGACNLDDAL SVRDLGPVYE VAVHIADVAS LVPKDGALDV 1620
EARQQGTVFY APNREPVLML PASLCQDALS LLPGQDRLAI SLFLTMEKGG GQIKSLRFAP 1680
SIIRSDRQLS YEEAEELIKR HPGAGLELPA HLDSVEACVV AACYFSWMLR RQRLSAACYY 1740
EPPDEDSVLG FRTAHIMVQE YMIQFNSHVA EFLVSNKHTQ TLTPLRWQPT PSRQQLDSVF 1800
KKYRGLVPLS LHLCHHSNTD YTPNKQLHLL TSLWKQVQLA AGTQDYSQMV DLIAADDMHP 1860
SLAPACLDLR RALGRSVFGR SSQGKQQPAV HHSLQVDWYT WATSPIRRYL DVVLQRLILL 1920
ALGHRGSTYS NRDIDGLCLD FSRQYASAQS YQRRAYSLHL AIQLKSQPQN KLGFVVDVEM 1980
GARCFKVLFP INRETLPDPC PIHYHSLQLA EHPQELVSQT GVRLVWRRRM YSVQASKLPL 2040
PLLGTSLDPH TQTVDAALWM KLLMLLKEQR WPEIAALIQE QDKRFHPREK VKIHQSRCGH 2100
FVEVVYELGS GDTLQVQLGS SLQRGFLAPT LKLWTVVPGF SLCLEHMERP GDCFSSHVHQ 2160
ALQDQYLQVG EYSGAWGPRC ALESLTNAVT ENDSIVLHDV HISWDTSQGQ LQGTFQLEAA 2220
FLQEKCINIH FGCCYLCIRL EGLPLPLDSS LPGPSGLGPF LNIDPNTYTW VAHGLSGDWD 2280
HELAGGDWDQ ENVDDRQEAP KQVYFLIHHM TMEKVPEEVL RPSARFTVEV LSKQLPDLRK 2340
EEAVRQLKTA SPLVISIALG LPIPEIRWPI SGPRRLVSEL RWPIPGPRRP VSEPHRPMSG 2400
PCGPISEPCR SIPEPCRGNW PRQHSFHKAS TSRFLERQNY NIPAGHHKLN QSQDRAVRSA 2460
LQKQFTVIQG PPGTGKTVVG FHIVYWFHRS NQEQMPTDSS PSGEEQLGGP CVLYCGPSNK 2520
SVDVLGGLLL RRKTEMKPLR VYGEQAEATE FPLPGVSNRS LFGKTSQEGR PNQSLRSITL 2580
HHRIRQAPNP YAAEIRKFDA QLREGKIFSK EDLRVYRRVL GKARKHELER HSVILCTCSC 2640
AASKSLKILN VRQILIDEAG MATEPETLIP LVCFSKTVEK VVLLGDHKQL RPVVKSEQLQ 2700
SLGMDRSLFE RYHRDAIMLD TQYRMHKDIC SFPSVEFYGG KLKTWSDLRR LPSILGHTGK 2760
PSCSVIFGSV QGHEQKLLVS TEDGNENSRA NPEEVTQVVR IIKQLTLDRT VDPKDIAVLT 2820
PYNAQAAAIS RGLMQRGVTG VTVTSITKSQ GSEWRYVIVS TVRTCPRSDV DQRPTKSWLK 2880
KFLGFVVDPH QVNVAITRAQ EALCIIGDHL LLRCCPLWHR LLDFCEAQHS LVSAEKVRVQ 2940
RKSALSS 2947 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara.
 GO:0004540; F:ribonuclease activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR027417; P-loop_NTPase.
 IPR026855; PRIC285.
 IPR001900; RNase_II/R. 
Pfam
 PF00773; RNB 
SMART
 SM00382; AAA
 SM00955; RNB 
PROSITE
  
PRINTS