| Tag | Content |
|---|
| CPLM ID | CPLM-005007 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Translocation protein SEC62 |
Protein Synonyms/Alias | Sec62/63 complex 30 kDa subunit |
Gene Name | SEC62 |
Gene Synonyms/Alias | YPL094C; LPG14C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 270 | KKKAINEKAEQN*** | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. In an initial step, the signal sequence seems to bind simultaneously to SEC61 and SEC62. SEC62 and SEC63 are required for interactions between SEC61 and translocating polypeptides. SEC62 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC62 is essential for cell growth. |
Sequence Annotation | |
Keyword | Complete proteome; Endoplasmic reticulum; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 274 AA |
Protein Sequence | MSAVGPGSNA GASVNGGSAT AIATLLRNHK ELKQRQGLFQ AKQTDFFRYK RFVRALHSEE 60
YANKSARQPE IYPTIPSNKI EDQLKSREIF IQLIKAQMVI PVKKLHSQEC KEHGLKPSKD 120
FPHLIVSNKA QLEADEYFVW NYNPRTYMDY LIVIGVVSII LALVCYPLWP RSMRRGSYYV 180
SLGAFGILAG FFAVAILRLI LYVLSLIVYK DVGGFWIFPN LFEDCGVLES FKPLYGFGEK 240
DTYSYKKKLK RMKKKQAKRE SNKKKAINEK AEQN 274 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:InterPro. GO:0016021; C:integral to membrane; ISM:SGD. GO:0031207; C:Sec62/Sec63 complex; IPI:SGD. GO:0008565; F:protein transporter activity; TAS:SGD. GO:0031204; P:posttranslational protein targeting to membrane, translocation; IDA:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |