CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate kinase 
Protein Synonyms/Alias
  
Gene Name
 PFF1300w 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
79HGSHEDHKEMFNNVLacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Glycolysis; Kinase; Magnesium; Pyruvate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 511 AA 
Protein Sequence
MSSFKYKNSA AGASMQSAAN ITLRQILEPN NVNLRSKKTH IVCTLGPACK SVETLVKLID 60
AGMDICRFNF SHGSHEDHKE MFNNVLKAQE LRPNCLLGML LDTKGPEIRT GFLKNKEVHL 120
KEGSKLKLVT DYEFLGDETC IACSYKKLPQ SVKPGNIILI ADGSVSCKVL ETHEDHVITE 180
VLNSAVIGER KNMNLPNVKV DLPIISEKDK NDILNFAIPM GCNFIAASFI QSADDVRLIR 240
NLLGPRGRHI KIIPKIENIE GIIHFDKILA ESDGIMIARG DLGMEISPEK VFLAQKLMIS 300
KCNLQGKPII TATQMLESMT KNPRPTRAEV TDVANAVLDG TDCVMLSGET AGGKFPVEAV 360
TIMSKICLEA EACIDYKLLY QSLVNAIETP ISVQEAVARS AVETAESIQA SLIIALTETG 420
YTARLIAKYK PSCTILALSA SDSTVKCLNV HRGVTCIKVG SFQGTDIVIR NAIEIAKQRN 480
MAKVGDSVIA IHGIKEEVSG GTNLMKVVQI E 511 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR018209; Pyrv_Knase_AS.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 
Pfam
 PF00224; PK
 PF02887; PK_C 
SMART
  
PROSITE
 PS00110; PYRUVATE_KINASE 
PRINTS
 PR01050; PYRUVTKNASE.