| Tag | Content |
|---|
| CPLM ID | CPLM-026176 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pyruvate dehydrogenase E1 component |
Protein Synonyms/Alias | |
Gene Name | TTHA0185 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 429 | NVAHQVKKLTEEDLK | acetylation | [1] |
|
Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Oxidoreductase; Pyruvate; Reference proteome; Thiamine pyrophosphate. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 905 AA |
Protein Sequence | MTEKELKAAF QALSPEEKAR FLEIENREWL ESLEYVLKVE GPERVEELLR LLDEYLFRHG 60
VYPANRLSTP YLNTLPKEKE PPYPGDLELE RRIANILRWN VAMMVTRANK KADGIGGHIA 120
TYASIAELYE VGFNHFFRGP EAGLDRDLVF FQGHASPGNY ARAFLEGRLK EEDLENFRRE 180
VHPPVPGGRG LSSYPHPWLM PDFWEFPTVS MGLGPIQAIY QARFMRYLED RGLKPKSSAK 240
VWAFLGDGEH DEPETVGALH LAARENLDNL IFVVNCNLQR LDGPVRGNSK VIQELERLYR 300
GAGWRVIKVV WGSAWDELLA KDKEGHLLRR FEALVDGESQ RYAAFGGKEL RERFFNTPEL 360
KKLIEGMTDE ELTELTRSRG GHDMVKIYAA YKAAVEHRGS PVVILARTIK GYGMGPTVMA 420
KNVAHQVKKL TEEDLKEARR FLGIPIPEEK LPELPYYHPG PDSPEVRYLL ERRKALGGFV 480
PERRVRFQGG LEVPEEEFFR EFYEGSGGRE ISTTMAFVRI LAKLLRHPKI GKYIVPIVPD 540
EARTFGMEAL IAQVGVYSPQ GQLYVPVDAG TLTAYKESQK GQILEEGITE AGAMAEFIAA 600
GTAYAHWGIP TIPFFITYSM FGLQRIGDLV WAAADQRARG FFLGATAGRT TLAGEGLQHQ 660
DGQSHVYALA APNLLAYDPA FAYEFAVILE DGLRRMYGRG EDVFYYITIE NENYVHPPMP 720
EPREKVKEGI LKGLYLFRAG EGKGPKVQLF GTGPILNEAL KAQELLAKYG VVADVWSATS 780
YKALYVDAIE AERETRLLGK ARRPYVQEAL EGHEGPIVAA TDYLKALPNL IRGYVDRPFA 840
VLGTDGFGRS DTREALRDFF EVDARHIAYT ALALLHGEGK VTKRTLNQAR KDLGLKLEEV 900
PPHRR 905 |
Gene Ontology | GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:EC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |