UniProt Accession

 SNX10_HUMAN; Q9Y5X0; E9PFH5; Q8IYT5 

Genbank Protein ID

 AF121860; AK309162; AK312850; AC004540; AC010677; AC074295; CH236948; CH471073; BC034992 

Genbank Nucleotide ID

 AAD27833.1; BAG35703.1; EAL24234.1; EAW93849.1; AAH34992.1 

Protein Name

 Sorting nexin-10 

Protein Synonyms/Alias

  

Gene Name

 SNX10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	QLPELPSKNLFFNMN	ubiquitination	[1]
148	SVEEAIHKFALMNRR	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. 

Sequence Annotation

 DOMAIN 10 127 PX.
 REGION 8 125 Required for the interaction with
 BINDING 53 53 Phosphatidylinositol 3-phosphate
 BINDING 79 79 Phosphatidylinositol 3-phosphate
 BINDING 94 94 Phosphatidylinositol 3-phosphate  

Keyword

 Alternative splicing; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Endosome; Lipid-binding; Membrane; Osteopetrosis; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0031313; C:extrinsic to endosome membrane; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005545; F:1-phosphatidylinositol binding; IMP:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0042384; P:cilium assembly; IMP:UniProtKB.
 GO:0007032; P:endosome organization; IMP:UniProtKB.
 GO:0030316; P:osteoclast differentiation; ISS:UniProtKB.
 GO:0071539; P:protein localization to centrosome; IMP:UniProtKB.
 GO:0061512; P:protein localization to cilium; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR001683; Phox. 

Pfam

 PF00787; PX 

SMART

 SM00312; PX 

PROSITE

 PS50195; PX 

PRINTS