CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prothymosin alpha 
Protein Synonyms/Alias
 Prothymosin alpha, N-terminally processed; Thymosin alpha 
Gene Name
 Ptma 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
15TSSEITTKDLKEKKEacetylation[1, 2, 3]
15TSSEITTKDLKEKKEsuccinylation[3]
103EDDDVDTKKQKTEEDacetylation[1, 3, 4]
103EDDDVDTKKQKTEEDubiquitination[5]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylserine; in Prothymosin alpha, N-
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 8 8 Phosphothreonine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 13 13 Phosphothreonine (By similarity).
 MOD_RES 14 14 Phosphothreonine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 102 102 Phosphothreonine (By similarity).
 MOD_RES 107 107 Phosphothreonine (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 111 AA 
Protein Sequence
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD NEVDEEEEEG 60
GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV DTKKQKTEED D 111 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR004931; Pro/parathymosin. 
Pfam
 PF03247; Prothymosin 
SMART
  
PROSITE
  
PRINTS