CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015877
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongator complex protein 1 
Protein Synonyms/Alias
 ELP1; IkappaB kinase complex-associated protein; IKK complex-associated protein 
Gene Name
 Ikbkap 
Gene Synonyms/Alias
 Elp1; Ikap 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
707TVVPQDTKLILQMPRacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity). 
Sequence Annotation
 MOD_RES 1172 1172 Phosphoserine (By similarity).
 MOD_RES 1175 1175 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1333 AA 
Protein Sequence
MRNLKLHRTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVRRE VKTEISLVAE 60
GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNLSTQ QLECVGSVAS GISVMSWSPD 120
QELLLLATAQ QTLIMMTKDF EVIAEEQIHQ DDFGEGKFVT VGWGSKQTQF HGSEGRPTAF 180
PVQLPENALP WDDRRPHITW RGDGQYFAVS VVCRQTEARK IRVWNREFAL QSTSESVPGL 240
GPALAWKPSG SLIASTQDKP NQQDVVFFEK NGLLHGHFTL PFLKDEVKVN DLLWNADSSV 300
LAIWLEDLPK EDSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL WDPVTPCRLH 360
VLCTGWRYLC CDWHWTTDRS SGNSANDLAN VAVIDGNRVL VTVFRQTVVP PPMCTYRLLI 420
PHPVNQVIFS AHLGNDLAVL DASNQISVYK CGDKPNMDST VKLGAVGGNG FKVPLTTPHL 480
EKRYSIQFGN NEEEEEEEVN ALQLSFLTWV EDDTFLAISY SHSSSQSIIH HLTVTHSEVD 540
EEQGQLDVSS SVTVDGVVIG LCCCSKTKSL AVQLADGQVL KYLWESPSLA VEPWKNSEGI 600
PVRFVHPCTQ MEVATIGGEE CVLGLTDRCR FFINDTEVAS NITSFAVCDD FLLVTTHSHT 660
CQVFSLSGAS LKMLQAALSG SHEASGEILR KVERGSRIVT VVPQDTKLIL QMPRGNLEVV 720
HHRALVLAQI RKWLDKLMFK EAFECMRKLR INLNLIHDHN PKVFLENVET FVKQIDSVNH 780
INLFFTELRE EDVTKTMYPP PITKSVQVST HPDGKKLDLI CDAMRAAMEA INPRKFCLSI 840
LTSHVKKTTP ELEIVLQKVQ ELQGNLPFDP ESVSVEEALK YLLLLVDVNE LFNHSLGTYD 900
FNLVLMVAEK SQKDPKEYLP FLNTLKKMET NYQRFTIDKY LKRYEKALGH LSKCGPEYFT 960
ECLNLIKDKN LYKEALKLYR PDSPQYQAVS MAYGEHLMQE HLYEPAGLVF ARCGAQEKAL 1020
EAFLACGSWQ QALCVAAQLQ MSKDKVAGLA RTLAGKLVEQ RKHSEAATVL EQYAQDYEEA 1080
VLLLLEGSAW EEALRLVYKY DRVDIIETSV KPSILEAQKN YMDFLDSETA TFIRHKNRLQ 1140
VVRALRRQAP QVHVDHEVAH GPESDLFSET SSIMSGSEMS GRYSHSNSRI SARSSKNRRK 1200
AERKKHSLKE GSPLEGLALL EALSEVVQSV EKLKDEVRAI LKVLFLFEFE EQAKELQRAF 1260
ESTLQLMERA VPEIWTPAGQ QSSTTPVLGP SSTANSITAS YQQQKTCVPA LDAGVYMPPK 1320
MDPRSQWKLS LLE 1333 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IEA:Compara.
 GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0008023; C:transcription elongation factor complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0008607; F:phosphorylase kinase regulator activity; ISS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR006849; IKI3. 
Pfam
 PF04762; IKI3 
SMART
  
PROSITE
  
PRINTS