CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026240
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat-containing protein WRAP73 
Protein Synonyms/Alias
  
Gene Name
 WRAP73 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15KLSSLLCKFSPDGKYubiquitination[1]
21CKFSPDGKYLASCVQubiquitination[1]
231DPKIVVYKEAEKSPQubiquitination[1, 2, 3, 4]
262PLPSSESKYEIASVPubiquitination[1, 2, 3, 4]
276PVSLQTLKPVTDRANubiquitination[1, 2, 3, 4]
285VTDRANPKIGIGMLAubiquitination[1, 3, 4, 5]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 304 AA 
Protein Sequence
MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ IQHIEWSADS 60
LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS 120
LCTKSVSYIK YPKACLQGIT FTRDGRYMAL AERRDCKDYV SIFVCSDWQL LRHFDTDTQD 180
LTGIEWAPNG CVLAVWDTCL EVRILNHVTW KMITEFGHPA AINDPKIVVY KEAEKSPQLG 240
LGCLSFPPPR AGAGPLPSSE SKYEIASVPV SLQTLKPVTD RANPKIGIGM LAFSPDSYFL 300
ATRN 304 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS