CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5'-nucleotidase domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 NT5DC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102DILIEHYKYPEGIRKubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 ACT_SITE 73 73 Nucleophile (By similarity).
 ACT_SITE 75 75 Proton donor (By similarity).
 METAL 73 73 Magnesium (By similarity).
 METAL 75 75 Magnesium; via carbonyl oxygen (By
 METAL 358 358 Magnesium (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Hydrolase; Magnesium; Metal-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MRVESGSAQE RGILLESLST LLEKTTASHE GRAPGNRELT DLLPPEVCSL LNPAAIYANN 60
EISLRDVEVY GFDYDYTLAQ YADALHPEIF STARDILIEH YKYPEGIRKY DYNPSFAIRG 120
LHYDIQKSLL MKIDAFHYVQ LGTAYRGLQP VPDEEVIELY GGTQHIPLYQ MSGFYGKGPS 180
IKQFMDIFSL PEMALLSCVV DYFLGHSLEF DQAHLYKDVT DAIRDVHVKG LMYQWIEQDM 240
EKYILRGDET FAVLSRLVAH GKQLFLITNS PFSFVDKGMR HMVGPDWRQL FDVVIVQADK 300
PSFFTDRRKP FRKLDEKGSL QWDRITRLEK GKIYRQGNLF DFLRLTEWRG PRVLYFGDHL 360
YSDLADLMLR HGWRTGAIIP ELEREIRIIN TEQYMHSLTW QQALTGLLER MQTYQDAESR 420
QVLAAWMKER QELRCITKAL FNAQFGSIFR TFHNPTYFSR RLVRFSDLYM ASLSCLLNYR 480
VDFTFYPRRT PLQHEAPLWM DQLCTGCMKT PFLGDMAHIR 520 
Gene Ontology
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR023214; HAD-like_dom.
 IPR008380; HAD-SF_hydro_IG_5-nucl.
 IPR016695; Pur_nucleotidase. 
Pfam
 PF05761; 5_nucleotid 
SMART
  
PROSITE
  
PRINTS