CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell adhesion molecule 4 
Protein Synonyms/Alias
 Immunoglobulin superfamily member 4C; IgSF4C; Nectin-like protein 4; NECL-4; TSLC1-like protein 2 
Gene Name
 Cadm4 
Gene Synonyms/Alias
 Igsf4c; Necl4; Tsll2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
352VWCSVRQKGSYLTHEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. 
Sequence Annotation
 DOMAIN 21 119 Ig-like V-type.
 DOMAIN 124 219 Ig-like C2-type 1.
 DOMAIN 224 307 Ig-like C2-type 2.
 MOD_RES 361 361 Phosphoserine.
 CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
 CARBOHYD 67 67 N-linked (GlcNAc...) (Potential).
 CARBOHYD 286 286 N-linked (GlcNAc...) (Potential).
 DISULFID 44 104 By similarity.
 DISULFID 145 199 By similarity.
 DISULFID 245 291 By similarity.  
Keyword
 Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MGRARRFQWP LLLLWAAAAG PGTGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA 60
RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV 120
LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAAVLRWYR DRKELKGVSS GQENGKVWSV 180
ASTVRFRVDR KDDGGIVICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT 240
LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEAANKHGHA 300
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA 360
SGLDEQGEAR EAFLNGGDGH KRKEEFFI 388 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set.
 IPR003585; Neurexin-like. 
Pfam
 PF08205; C2-set_2
 PF07686; V-set 
SMART
 SM00294; 4.1m
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS