CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Scavenger receptor class B member 1 
Protein Synonyms/Alias
 SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD36 
Gene Name
 SCARB1 
Gene Synonyms/Alias
 CD36L1; CLA1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
184GEIMWGYKDPLVNLIubiquitination[1]
288RSMKLMYKESGVFEGubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). 
Sequence Annotation
 CARBOHYD 102 102 N-linked (GlcNAc...).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 255 255 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 330 330 N-linked (GlcNAc...).
 CARBOHYD 383 383 N-linked (GlcNAc...) (Potential).
 DISULFID 251 384 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Membrane; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 552 AA 
Protein Sequence
MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP 60
IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ 120
FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM 180
WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL 240
SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR 300
FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG 360
LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG 420
AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH 480
SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE 540
GLGPSLGGGT GS 552 
Gene Ontology
 GO:0005901; C:caveola; TAS:BHF-UCL.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0031528; C:microvillus membrane; IEA:Compara.
 GO:0005545; F:1-phosphatidylinositol binding; TAS:BHF-UCL.
 GO:0008035; F:high-density lipoprotein particle binding; IEA:Compara.
 GO:0070506; F:high-density lipoprotein particle receptor activity; IDA:BHF-UCL.
 GO:0001530; F:lipopolysaccharide binding; IDA:BHF-UCL.
 GO:0001875; F:lipopolysaccharide receptor activity; IDA:BHF-UCL.
 GO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL.
 GO:0001786; F:phosphatidylserine binding; ISS:BHF-UCL.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0051856; P:adhesion to symbiont; IMP:BHF-UCL.
 GO:0006702; P:androgen biosynthetic process; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0006707; P:cholesterol catabolic process; IEA:Compara.
 GO:0033344; P:cholesterol efflux; ISS:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL.
 GO:0070508; P:cholesterol import; ISS:BHF-UCL.
 GO:0032497; P:detection of lipopolysaccharide; IDA:BHF-UCL.
 GO:0001935; P:endothelial cell proliferation; IEA:Compara.
 GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; ISS:BHF-UCL.
 GO:0006629; P:lipid metabolic process; TAS:Reactome.
 GO:0015920; P:lipopolysaccharide transport; IDA:BHF-UCL.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0034383; P:low-density lipoprotein particle clearance; ISS:BHF-UCL.
 GO:0015914; P:phospholipid transport; ISS:BHF-UCL.
 GO:0010886; P:positive regulation of cholesterol storage; IDA:BHF-UCL.
 GO:0010595; P:positive regulation of endothelial cell migration; TAS:BHF-UCL.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:BHF-UCL.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:BHF-UCL.
 GO:0043654; P:recognition of apoptotic cell; IDA:BHF-UCL.
 GO:0050764; P:regulation of phagocytosis; IC:BHF-UCL.
 GO:0010899; P:regulation of phosphatidylcholine catabolic process; ISS:BHF-UCL.
 GO:0043691; P:reverse cholesterol transport; IEP:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0070328; P:triglyceride homeostasis; ISS:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW.
 GO:0042060; P:wound healing; TAS:BHF-UCL. 
Interpro
 IPR002159; CD36.
 IPR005428; CD36_antigen. 
Pfam
 PF01130; CD36 
SMART
  
PROSITE
  
PRINTS
 PR01610; CD36ANTIGEN.
 PR01609; CD36FAMILY.