| Tag | Content |
|---|
| CPLM ID | CPLM-001048 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heme oxygenase 2 |
Protein Synonyms/Alias | HO-2 |
Gene Name | Hmox2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 198 | VDNAQQFKQFYRARM | ubiquitination | [1] | | 213 | NALDLNLKTKERIVE | ubiquitination | [1] | | 258 | GLPVHDGKGDIRKCP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. |
Sequence Annotation | REPEAT 263 268 HRM 1.
REPEAT 280 285 HRM 2.
METAL 44 44 Iron (heme axial ligand) (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity). |
Keyword | Acetylation; Complete proteome; Endoplasmic reticulum; Heme; Iron; Metal-binding; Microsome; Oxidoreductase; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 315 AA |
Protein Sequence | MSSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT QFVKDFLKGN 60
IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT ELHRKAALIK DMKYFFGENW 120
EEQVKCSEAA QKYVDRIHYV GQNEPELLVA HAYTRYMGDL SGGQVLKKVA QRALKLPSTG 180
EGTQFYLFEH VDNAQQFKQF YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG 240
SMLARETLED GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA 300
ASVALVAGLL AWYYM 315 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:Compara. GO:0004392; F:heme oxygenase (decyclizing) activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006788; P:heme oxidation; IEA:InterPro. GO:0001666; P:response to hypoxia; IEA:Compara. GO:0006979; P:response to oxidative stress; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |