| Tag | Content |
|---|
| CPLM ID | CPLM-011551 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Protein Synonyms/Alias | 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24 |
Gene Name | CYP24A1 |
Gene Synonyms/Alias | CYP24 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 400 | FTTRTLDKATVLGEY | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. |
Sequence Annotation | METAL 462 462 Iron (heme axial ligand) (Potential). |
Keyword | Alternative splicing; Complete proteome; Disease mutation; Heme; Iron; Metal-binding; Mitochondrion; Monooxygenase; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 514 AA |
Protein Sequence | MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG 60
PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR 120
TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN 180
EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM 240
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD 300
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL 360
PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ 420
VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV 480
RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR 514 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IDA:UniProtKB. GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IEA:Compara. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; TAS:UniProtKB. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0001649; P:osteoblast differentiation; IEP:BHF-UCL. GO:0042369; P:vitamin D catabolic process; NAS:BHF-UCL. GO:0070561; P:vitamin D receptor signaling pathway; NAS:BHF-UCL. GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. |
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SMART | |
PROSITE | |
PRINTS | |