CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019904
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable histidine--tRNA ligase, mitochondrial 
Protein Synonyms/Alias
 Histidine--tRNA ligase-like; Histidyl-tRNA synthetase; HisRS 
Gene Name
 Hars2 
Gene Synonyms/Alias
 Harsl 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
447MLYKNNPKLLTQLHYacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 443 443 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MPHLGPLRRR AWAALLGQLL RPPSTVCTRG CHSQVAKAVL TSEQLKSHQE KPNFVIKVPK 60
GTRDLSPQQM VVREKILDKI ISCFKRHGAK GLDTPAFELK EMLTEKYEDN FGLMYDLKDQ 120
GGELLSLRYD LTVPFARYLA MNKLKKMKRY QVGKVWRRES PAIAQGRYRE FCQCDFDIAG 180
EFDPMIPDAE CLRIMCEILS GLQLGDFLIK VNDRRVVDGI FAVCGVPESK LRTICSSMDK 240
LDKMSWEGVR HEMVAKKGLA PEVADRIGDF VQYHGGISLV EDLFKDPRLS QSQLALQGLG 300
DLKLLFEYLR LFGIADKISL DLSLARGLDY YTGVIYEAVL LESPAQAGKE TLSVGSVAAG 360
GRYDNLVAQF DPKGHHVPCV GLSIGVERIF YLVEQKMKMS GEKVRTTETQ VFVATPQKNF 420
LQERLKIIAE LWDAGIKAEM LYKNNPKLLT QLHYCEKADI PLMVIIGEQE RNEGVIKLRS 480
VASREEVTIN RESLVAEIQK RLSES 505 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004821; F:histidine-tRNA ligase activity; IEA:EC.
 GO:0006427; P:histidyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR015807; His-tRNA-ligase.
 IPR004516; HisRS/HisZ. 
Pfam
 PF03129; HGTP_anticodon 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS