CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016791
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 53 homolog 
Protein Synonyms/Alias
  
Gene Name
 Vps53 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
253NILDPRIKQEIIKKFacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (By similarity). 
Sequence Annotation
 MOD_RES 110 110 N6-acetyllysine (By similarity).
 MOD_RES 360 360 N6-acetyllysine (By similarity).
 MOD_RES 377 377 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphothreonine (By similarity).
 MOD_RES 580 580 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 832 AA 
Protein Sequence
MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDQA DFNAVEYINT LFPTEQSLAN 60
IDDVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQALEEA QKAIQQLFGK IKDIKDKAEK 120
SEQMVKEITR DIKQLDHAKR HLTTSITTLN HLHMLAGGVD SLEAMTRRRQ YGEVANLLQG 180
VMNVLEHFHK YMGIPQIRQL SERVKAAQTE LGQQILADFE EAFPSQGTKR PGGPSNVLRD 240
ACLVANILDP RIKQEIIKKF IKQHLSEYLV LFQENQDVAW LDKIDRRYAW VKRQLVDYEE 300
KYGRMFPREW CMTERISVEF CHVTRAELSK IMRARAKEIE VKLLLFAIQR TTNFEGFLAK 360
RFSGCTLTDG TLKKLESPPP STNPFLEDET TPEMEELALE KGELEQPKKP KAPDNPFHGI 420
VSKCFEPHLY VYIESQDKNL SELIDRFVAD FKAQGPPKPN TDEGGAVLPS CADLFVYYKK 480
CMVQCSQLST GEPMIALTTI FQKYLREYAW KILSGNLPKT SSSSGGLTIS SLLKEKEGSE 540
VARFTLEELC LICSILSTAE YCLATTQQLE EKLKEKVDVS LTERINLTGE MDTFSTVISS 600
SIQLLVQDLD AACDPALIAM SKMPWQNVEH VGDQSPYVTS VILHIKQNVP IIRDNLASTR 660
KYFTQFCIKF ANSFIPKFIT HLFKCKPISM VGAEQLLLDT HSLKMVLLDL PSIGSQVVRK 720
APASYTKIVV KGMTRAEMIL KVVMAPHEPL VVFVDNYIKL LTDCNSETFQ KILDMKGLKR 780
SEQSSMLELL RQRLPAPPSG TEGSSTLSLI APTPEQESSR IRKLEKLIKK RL 832 
Gene Ontology
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000938; C:GARP complex; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR007234; Vps53_N. 
Pfam
 PF04100; Vps53_N 
SMART
  
PROSITE
  
PRINTS