Tag | Content |
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CPLM ID | CPLM-006486 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histidine ammonia-lyase |
Protein Synonyms/Alias | Histidase |
Gene Name | Hal |
Gene Synonyms/Alias | Hsd; Huth |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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172 | GITTGFGKFARTVIP | ubiquitination | [1] | 182 | RTVIPANKLQELQVN | ubiquitination | [1] | 200 | SHSSGVGKPLSPERC | ubiquitination | [1] | 220 | LRINVLAKGYSGISL | ubiquitination | [1] | 277 | EGKMWSPKSGWADAK | ubiquitination | [1] | 293 | VLEAHGLKPIVLKPK | ubiquitination | [1] | 298 | GLKPIVLKPKEGLAL | ubiquitination | [1] | 300 | KPIVLKPKEGLALIN | ubiquitination | [1] | 342 | ALTLEVLKGTTKAFD | ubiquitination | [1] | 346 | EVLKGTTKAFDTDIH | ubiquitination | [1] | 578 | KTTTPLEKVYDLVRS | ubiquitination | [1] | 592 | SVVRPWIKDRFMAPD | ubiquitination | [1] | 611 | HRLLLDQKVWEVAAP | ubiquitination | [1] | 622 | VAAPYIEKYRMEHIP | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | MOD_RES 254 254 2,3-didehydroalanine (Ser) (By MOD_RES 631 631 Phosphoserine. MOD_RES 635 635 Phosphoserine. MOD_RES 648 648 Phosphoserine. CROSSLNK 253 255 5-imidazolinone (Ala-Gly) (By |
Keyword | Complete proteome; Disease mutation; Histidine metabolism; Lyase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 657 AA |
Protein Sequence | MPRYTVHVRG EWLAVPCQDG KLTVGWLGRE AVRRYMKNKP DNGGFTSVDE VQFLVHRCKG 60 LGLLDNEDEL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG VFLYSKYREP EKYIALDGDS 120 LSTEDLVNLG KGRYKIKLTS IAEKKVQQSR EVIDSIIKER TVVYGITTGF GKFARTVIPA 180 NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEAFNAS 240 CLSYVPEKGT VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 300 EGLALINGTQ MITSLGCEAL ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHAVRPHRG 360 QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKDIITT 420 ELNSATDNPM VFASRGETIS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS 480 ELPAFLVAEG GLNSGFMIAH CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR 540 KALRVVEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600 EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT IPESDDL 657 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0004397; F:histidine ammonia-lyase activity; IDA:MGI. GO:0009058; P:biosynthetic process; IEA:InterPro. GO:0006548; P:histidine catabolic process; IDA:MGI. GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway. GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |