| Tag | Content |
|---|
| CPLM ID | CPLM-022384 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PH and SEC7 domain-containing protein 3 |
Protein Synonyms/Alias | Epididymis tissue protein Li 20mP; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Hepatocellular carcinoma-associated antigen 67; Pleckstrin homology and SEC7 domain-containing protein 3 |
Gene Name | PSD3 |
Gene Synonyms/Alias | EFA6R; HCA67; KIAA0942 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 615 | GKNNEFSKLVAEEYL | ubiquitination | [1] | | 941 | KSHESKLKQITTELA | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Guanine nucleotide exchange factor for ARF6 (By similarity). |
Sequence Annotation | DOMAIN 534 734 SEC7.
DOMAIN 785 898 PH.
MOD_RES 770 770 Phosphoserine.
MOD_RES 1011 1011 Phosphoserine (By similarity).
MOD_RES 1012 1012 Phosphoserine (By similarity).
MOD_RES 1020 1020 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1048 AA |
Protein Sequence | MEGRSAAAET FVWVNNASAH SQSVAKAKYE FLFGRSEGKA PDTSDHGGST LLPPNVTNEF 60
PEYGTMEEGG EGLRASLEFD GEALPCHPQE QQGVQPLTGC HSGLDSVTEG PKDVREAPSQ 120
SHLKEQSLQP IDSLISALKA TEARIISGTL QATKVLDQDA VSSFSVQQVE KELDTASRKT 180
QRVNKTLPAG QKNLPEIPLS AEVTTEESFY LSIQKDLTAL LTGDTQAEIS QIMNNGRKGA 240
VCVQEPSCPL ASLGSSAVTC HSAGSVGFLK EQRSALGREH PGGCDRSSSM GRPGRVKHVE 300
FQGVEILWTG GDKRETQHPI DFETSLQRTA SPDSKESSKV PRHLISSAGL CNSSSLTENV 360
WDESWKAPSE RPGTSSGTFS PVRLDESGED EVFLQENKQH LEKTPKPERD RERISEQEEH 420
VKGEDEDILG PGYTEDSTDV YSSQFETILD NTSLYYSAES LETLYSEPDS YFSFEMPLTP 480
MIQQRIKEGG QFLERTSGGG HQDILSVSAD GGIVMGYSSG VTNGLNDASD SIYTKGTPEI 540
AFWGSNAGVK TTRLEAHSEM GSTEILEKET PENLSNGTSS NVEAAKRLAK RLYQLDRFKR 600
SDVAKHLGKN NEFSKLVAEE YLKFFDFTGM TLDQSLRYFF KAFSLVGETQ ERERVLIHFS 660
NRYFYCNPDT IASQDGVHCL TCAIMLLNTD LHGHVNIGKK MTCQEFIANL QGVNEGVDFS 720
KDLLKALYNS IKNEKLEWAV DDEEKKKSPS ESTEEKANGT HPKTISRIGS TTNPFLDIPH 780
DPNAAVYKSG FLARKIHADM DGKKTPRGKR GWKTFYAVLK GTVLYLQKDE YKPEKALSEE 840
DLKNAVSVHH ALASKATDYE KKPNVFKLKT ADWRVLLFQT QSPEEMQGWI NKINCVAAVF 900
SAPPFPAAIG SQKKFSRPLL PATTTKLSQE EQLKSHESKL KQITTELAEH RSYPPDKKVK 960
AKDVDEYKLK DHYLEFEKTR YEMYVSILKE GGKELLSNDE SEAAGLKKSH SSPSLNPDTS 1020
PITAKVKRNV SERKDHRPET PSIKQKVT 1048 |
Gene Ontology | GO:0030054; C:cell junction; IBA:RefGenome. GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW. GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0030182; P:neuron differentiation; IBA:RefGenome. GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |