CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021933
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family B member 6, mitochondrial 
Protein Synonyms/Alias
 Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter 
Gene Name
 ABCB6 
Gene Synonyms/Alias
 MTABC3; PRP; UMAT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
418LLNFETVKYYNAESYubiquitination[1]
436RYREAIIKYQGLEWKubiquitination[1]
790EETSEDTKPQTMER*ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. 
Sequence Annotation
 DOMAIN 265 556 ABC transmembrane type-1.
 DOMAIN 590 824 ABC transporter.
 NP_BIND 623 630 ATP (Potential).  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Disease mutation; Endoplasmic reticulum; Golgi apparatus; Membrane; Microphthalmia; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 842 AA 
Protein Sequence
MVTVGNYCEA EGPVGPAWMQ DGLSPCFFFT LVPSTRMALG TLALVLALPC RRRERPAGAD 60
SLSWGAGPRI SPYVLQLLLA TLQAALPLAG LAGRVGTARG APLPSYLLLA SVLESLAGAC 120
GLWLLVVERS QARQRLAMGI WIKFRHSPGL LLLWTVAFAA ENLALVSWNS PQWWWARADL 180
GQQVRSAAQQ STWRDFGRKL RLLSGYLWPR GSPALQLVVL ICLGLMGLER ALNVLVPIFY 240
RNIVNLLTEK APWNSLAWTV TSYVFLKFLQ GGGTGSTGFV SNLRTFLWIR VQQFTSRRVE 300
LLIFSHLHEL SLRWHLGRRT GEVLRIADRG TSSVTGLLSY LVFNVIPTLA DIIIGIIYFS 360
MFFNAWFGLI VFLCMSLYLT LTIVVTEWRT KFRRAMNTQE NATRARAVDS LLNFETVKYY 420
NAESYEVERY REAIIKYQGL EWKSSASLVL LNQTQNLVIG LGLLAGSLLC AYFVTEQKLQ 480
VGDYVLFGTY IIQLYMPLNW FGTYYRMIQT NFIDMENMFD LLKEETEVKD LPGAGPLRFQ 540
KGRIEFENVH FSYADGRETL QDVSFTVMPG QTLALVGPSG AGKSTILRLL FRFYDISSGC 600
IRIDGQDISQ VTQASLRSHI GVVPQDTVLF NDTIADNIRY GRVTAGNDEV EAAAQAAGIH 660
DAIMAFPEGY RTQVGERGLK LSGGEKQRVA IARTILKAPG IILLDEATSA LDTSNERAIQ 720
ASLAKVCANR TTIVVAHRLS TVVNADQILV IKDGCIVERG RHEALLSRGG VYADMWQLQQ 780
GQEETSEDTK PQTMER 796 
Gene Ontology
 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; NAS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005774; C:vacuolar membrane; IBA:RefGenome.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0015562; F:efflux transmembrane transporter activity; IDA:UniProtKB.
 GO:0020037; F:heme binding; IDA:UniProtKB.
 GO:0015439; F:heme-transporting ATPase activity; IMP:UniProtKB.
 GO:0007420; P:brain development; IMP:UniProtKB.
 GO:0070574; P:cadmium ion transmembrane transport; IBA:RefGenome.
 GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB.
 GO:0071585; P:detoxification of cadmium ion; IBA:RefGenome.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IDA:UniProtKB.
 GO:0043588; P:skin development; IMP:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS