CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014011
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein wntless homolog 
Protein Synonyms/Alias
 Integral membrane protein GPR177; Protein evenness interrupted homolog; EVI; Putative NF-kappa-B-activating protein 373 
Gene Name
 WLS 
Gene Synonyms/Alias
 C1orf139; GPR177; UNQ85/PRO18667 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
206IRLPVNEKKKINVGIubiquitination[1]
207RLPVNEKKKINVGIGubiquitination[1]
208LPVNEKKKINVGIGEubiquitination[1]
217NVGIGEIKDIRLVGIubiquitination[1]
232HQNGGFTKVWFAMKTubiquitination[1]
410VFRNISGKQSSLPAMubiquitination[1]
419SSLPAMSKVRRLHYEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). 
Sequence Annotation
 REGION 101 232 Interacts with Wnt proteins (By  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Developmental protein; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MAGAIIENMS TKKLCIVGGI LLVFQIIAFL VGGLIAPGPT TAVSYMSVKC VDARKNHHKT 60
KWFVPWGPNH CDKIRDIEEA IPREIEANDI VFSVHIPLPH MEMSPWFQFM LFILQLDIAF 120
KLNNQIRENA EVSMDVSLAY RDDAFAEWTE MAHERVPRKL KCTFTSPKTP EHEGRYYECD 180
VLPFMEIGSV AHKFYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF 240
LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG 300
DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ 360
LTNPFYSIWT TDIGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV 420
RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGGVTVQVN SAFFTGIYGM 480
WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ 540
E 541 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; ISS:UniProtKB.
 GO:0009948; P:anterior/posterior axis specification; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR009551; Wntless. 
Pfam
  
SMART
  
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PRINTS