UniProt Accession

 D3Z6W1_MOUSE; D3Z6W1 

Genbank Protein ID

 AC111120; AC158748 

Genbank Nucleotide ID

  

Protein Name

 Microtubule-associated protein 6 

Protein Synonyms/Alias

  

Gene Name

 Map6 

Gene Synonyms/Alias

 Mtap6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	RFWNQLDKADIAVPL	ubiquitination	[1]
32	AVPLVFTKYSEATEH	ubiquitination	[1]
156	ERETQYQKDFRAWPL	ubiquitination	[1]
174	GDHPWIPKPVQIPAT	ubiquitination	[1]
193	QPVLGVPKRRPQSQE	ubiquitination	[1]
226	AGVLAAGKASGVDQR	ubiquitination	[1]
238	DQRDTRRKAGPAWMV	ubiquitination	[1]
254	RNEGHEEKPLPPAQS	ubiquitination	[1]
272	EGGPAAGKASGADQR	ubiquitination	[1]
300	RSEGHEEKPLPPAQS	ubiquitination	[1]
318	EGGPAAGKASGADQR	ubiquitination	[1]
364	EGGPAAGKASGADER	ubiquitination	[1]
376	DERDTRRKAGPAWMV	ubiquitination	[1]
406	GTGPEGGKGRAVADA	ubiquitination	[1]
441	FRAWTDIKPVKPIKA	acetylation	[2, 3]
441	FRAWTDIKPVKPIKA	ubiquitination	[1]
444	WTDIKPVKPIKAKPQ	acetylation	[3]
444	WTDIKPVKPIKAKPQ	ubiquitination	[1]
458	QYKPPDDKMVHETSY	ubiquitination	[1]
475	QFKGEANKPSAADNK	ubiquitination	[1]
482	KPSAADNKAMDRRRI	ubiquitination	[1]
498	SLYSEPFKECPKEPG	acetylation	[4]
498	SLYSEPFKECPKEPG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 509 AA 

Protein Sequence

Gene Ontology

 GO:0005874; C:microtubule; IEA:InterPro.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:InterPro. 

Interpro

 IPR024963; STOP/FAM154.
 IPR007882; STOP/MAP6. 

Pfam

 PF05217; STOP 

SMART

  

PROSITE

  

PRINTS