CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022632
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein sprouty homolog 2 
Protein Synonyms/Alias
 Spry-2 
Gene Name
 Spry2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
164ELKPGDVKPLSKDDLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. 
Sequence Annotation
 DOMAIN 177 291 SPR.  
Keyword
 Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Membrane; Microtubule; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 315 AA 
Protein Sequence
MEARAQSGNG SQPLLQTAHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPSQVH SSRAPLSRSI STVSSGSRSS 120
TRTSTSSSSS EQRLLGPSFS HGPAAADGII RVQPKSELKP GDVKPLSKDD LGLHAYRCED 180
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300
CKVPTVPPRN FEKPT 315 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:MGI.
 GO:0045165; P:cell fate commitment; IMP:MGI.
 GO:0042472; P:inner ear morphogenesis; IMP:MGI.
 GO:0060437; P:lung growth; IDA:MGI.
 GO:0060425; P:lung morphogenesis; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:MGI.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IDA:MGI.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:MGI.
 GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IDA:MGI.
 GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0034261; P:negative regulation of Ras GTPase activity; IDA:MGI.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:MGI.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IMP:MGI. 
Interpro
 IPR007875; Sprouty. 
Pfam
 PF05210; Sprouty 
SMART
  
PROSITE
 PS51227; SPR 
PRINTS