CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009042
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caveolin-3 
Protein Synonyms/Alias
 M-caveolin 
Gene Name
 CAV3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38NINEDIVKVDFEDVIsumoylation[1]
Reference
 [1] Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization.
 Fuhs SR, Insel PA.
 J Biol Chem. 2011 Apr 29;286(17):14830-41. [PMID: 21362625
Functional Description
 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. 
Sequence Annotation
 REGION 64 114 Required for interaction with DAG1.
 CROSSLNK 38 38 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Cardiomyopathy; Cell membrane; Complete proteome; Disease mutation; Golgi apparatus; Isopeptide bond; Limb-girdle muscular dystrophy; Long QT syndrome; Membrane; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 151 AA 
Protein Sequence
MMAEEHTDLE AQIVKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPVG TYSFDGVWKV 60
SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI 120
YSLCIRTFCN PLFAALGQVC SSIKVVLRKE V 151 
Gene Ontology
 GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; ISS:BHF-UCL.
 GO:0031594; C:neuromuscular junction; ISS:BHF-UCL.
 GO:0030315; C:T-tubule; ISS:BHF-UCL.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0005246; F:calcium channel regulator activity; IDA:BHF-UCL.
 GO:0071253; F:connexin binding; IDA:BHF-UCL.
 GO:0008022; F:protein C-terminus binding; IDA:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0032947; F:protein complex scaffold; ISS:BHF-UCL.
 GO:0017080; F:sodium channel regulator activity; IDA:BHF-UCL.
 GO:0007015; P:actin filament organization; IEA:Compara.
 GO:0055013; P:cardiac muscle cell development; IEA:Compara.
 GO:0070836; P:caveola assembly; IDA:MGI.
 GO:0016049; P:cell growth; ISS:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL.
 GO:0031122; P:cytoplasmic microtubule organization; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:BHF-UCL.
 GO:0090002; P:establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0042593; P:glucose homeostasis; ISS:BHF-UCL.
 GO:0060347; P:heart trabecula formation; IEA:Compara.
 GO:0046716; P:muscle cell homeostasis; ISS:BHF-UCL.
 GO:0007517; P:muscle organ development; TAS:UniProtKB.
 GO:0007520; P:myoblast fusion; IEA:Compara.
 GO:0051926; P:negative regulation of calcium ion transport; IDA:MGI.
 GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IMP:BHF-UCL.
 GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; IEA:Compara.
 GO:0045792; P:negative regulation of cell size; IMP:BHF-UCL.
 GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; ISS:BHF-UCL.
 GO:0060299; P:negative regulation of sarcomere organization; IMP:BHF-UCL.
 GO:0051647; P:nucleus localization; IEA:Compara.
 GO:0001778; P:plasma membrane repair; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0031116; P:positive regulation of microtubule polymerization; ISS:BHF-UCL.
 GO:0010831; P:positive regulation of myotube differentiation; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; ISS:BHF-UCL.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0090279; P:regulation of calcium ion import; IDA:BHF-UCL.
 GO:1901019; P:regulation of calcium ion transmembrane transporter activity; IDA:BHF-UCL.
 GO:0055117; P:regulation of cardiac muscle contraction; IMP:BHF-UCL.
 GO:0002027; P:regulation of heart rate; IMP:BHF-UCL.
 GO:1900825; P:regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; IMP:BHF-UCL.
 GO:0051394; P:regulation of nerve growth factor receptor activity; IMP:MGI.
 GO:1900744; P:regulation of p38MAPK cascade; IEA:Compara.
 GO:0051896; P:regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0038009; P:regulation of signal transduction by receptor internalization; IMP:MGI.
 GO:0014819; P:regulation of skeletal muscle contraction; IMP:BHF-UCL.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL.
 GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IDA:BHF-UCL.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IMP:BHF-UCL.
 GO:0033292; P:T-tubule organization; TAS:BHF-UCL.
 GO:0006641; P:triglyceride metabolic process; ISS:BHF-UCL. 
Interpro
 IPR001612; Caveolin.
 IPR018361; Caveolin_CS. 
Pfam
 PF01146; Caveolin 
SMART
  
PROSITE
 PS01210; CAVEOLIN 
PRINTS