CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Cit 
Protein Synonyms/Alias
  
Gene Name
 Cit 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1149LALQQALKEQKLKAEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2055 AA 
Protein Sequence
MLKFKYGVRN PSEASAPEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG VLDALFVLLE 60
ECSQPALMKI KHVSSFVRKY SDTIAELREL QPSVRDFEVR SLVGCGHFAE VQVVREKATG 120
DVYAMKIMKK AALRAQEQVS FFEEERNILS QSTSPWIPQL QYAFQDKNNL YLVMEYQPGG 180
DLLSLLNRYE DQLDENMIQF YLAELILAVH SVHQMGYVHR DIKPENILID RTGHIKLVDF 240
GSAAKMNSNK VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMLYGKT 300
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLIQSL LCVQKERLKF EGLCCHPFFA 360
RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSP CQLSPSGFSG EELPFVGFSY 420
SKALGYLGRS ESVVSGLDSP AKISSMEKKL LIKSKELQDS QDKCHKMEQE MARLHRRVSE 480
VEAVLSQKEV ELKASETQRS LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD 540
IREQSRKLQE IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR 600
KANECQHKLM KAKDLGKPEV GECSRLEKIN AEQQLKIQEL QEKLEKAVKA STEATELLQN 660
IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE NKVKRLETME RRENRLKDDI 720
QTKSEQIQQM ADKILELEEK HREAQVSAQH LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK 780
ESLETMMQRH EEEAHEKGKI LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ 840
RNMKAQEEMI SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKN RLLELETRLR 900
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT ELEETTAEAE 960
EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED NAELNNQNFY LSKQLDEASG 1020
ANDEIVQLRS EVDHLRREIT EREMQLTSQK QTMEALKTTC TMLEEQVMDL EALNDELLEK 1080
ERQWEAWRSV LGDEKSQFEC RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE 1140
ILALQQALKE QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL 1200
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK VKMEGTISQQ 1260
TKLIDFLQAK MDQPAKKKKV PLQYNELKLA LEKEKARCAE LEEALQKTRI ELRSAREEAA 1320
HRKATDHPHP STPATARQQI AMSAIVRSPE HQPSAMSLLA PPSSRRKEAS TPEEFSRRLK 1380
ERMHHNIPHR FNVGLNMRAT KCAVCLDTVH FGRQASKCLE CQVMCHPKCS TCLPATCGLP 1440
AEYATHFTEA FCRDKVSSPG LQSKEPSSSL HLEGWMKVPR NNKRGQQGWD RKYIVLEGSK 1500
VLIYDNEARE AGQRPVEEFE LCLPDGDVSI HGAVGASELA NTAKADVPYI LKMESHPHTT 1560
CWPGRTLYLL APSFPDKQRW VTALESVVAG GRVSREKAEA DAKLLGNSLL KLEGDDRLDM 1620
NCTLPFSDQV VLVGTEEGLY ALNVLKNSLT HIPGIGAVFQ IYIIKDLEKL LMIAGEERAL 1680
CLVDVKKVKQ SLAQSHLPAQ PDVSPNIFEA VKGCHLFAAG KIENSLCICA AMPSKVVILR 1740
YNDNLSKFCI RKEIETSEPC SCIHFTNYSI LIGTNKFYEI DMKQYTLEEF LDKNDHSLAP 1800
AVFASSTNSF PVSIVQANST GQREEYLLCF HEFGVFVDSY GRRSRTDDLK WSRLPLAFAY 1860
REPYLFVTHF NSLEVIEIQA RSSLGTPARA YLEIPNPRYL GPAISSGAIY LASSYQDKLR 1920
VICCKGNLVK ESGTEQHRVP STSRSSPNKR GPPTYNEHIT KRVASSPAPP EGPSHPREPS 1980
TPHRYRDREG RTELRRDKSP GRPLEREKSP GRMLSTRRER SPGRLFEDSS RGRLPAGAVR 2040
TPLSQVNKVW DQSSV 2055 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0031985; C:Golgi cisterna; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0005773; C:vacuole; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; TAS:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0017048; F:Rho GTPase binding; IMP:RGD.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
 GO:0000910; P:cytokinesis; IEA:Compara.
 GO:0016358; P:dendrite development; IEA:Compara.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:RGD.
 GO:0007030; P:Golgi organization; IMP:RGD.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IEA:Compara.
 GO:0000070; P:mitotic sister chromatid segregation; IEA:Compara.
 GO:0050774; P:negative regulation of dendrite morphogenesis; IEA:Compara.
 GO:0008064; P:regulation of actin polymerization or depolymerization; IDA:RGD.
 GO:0051726; P:regulation of cell cycle; NAS:RGD.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR001180; Citron.
 IPR017405; Citron_Rho-interacting_kinase.
 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR017892; Pkinase_C.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00780; CNH
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00109; C1
 SM00036; CNH
 SM00233; PH
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50219; CNH
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS